2107100 - Disclosure - Accrued Liabilities link:presentationLink link:calculationLink link:definitionLink 2407402 - Disclosure - Accrued Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 2307301 - Disclosure - Accrued Liabilities (Tables) link:presentationLink link:calculationLink link:definitionLink 2103100 - Disclosure - Available-for-Sale-Securities link:presentationLink link:calculationLink link:definitionLink 2403403 - Disclosure - Available-for-Sale-Securities - Classification on Consolidated Balance Sheets (Details) link:presentationLink link:calculationLink link:definitionLink 2403402 - Disclosure - Available-for-Sale-Securities - Summary of Available-for-Sale Securities (Details) link:presentationLink link:calculationLink link:definitionLink 2403404 - Disclosure - Available-for-Sale-Securities - Summary of Contractual Maturities (Details) link:presentationLink link:calculationLink link:definitionLink 2303301 - Disclosure - Available-for-Sale-Securities (Tables) link:presentationLink link:calculationLink link:definitionLink 2101100 - Disclosure - The Business link:presentationLink link:calculationLink link:definitionLink 1001000 - Statement - Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 1001501 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 1005000 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 1003000 - Statement - Consolidated Statements of Comprehensive Loss link:presentationLink link:calculationLink link:definitionLink 1004000 - Statement - Consolidated Statements of Equity link:presentationLink link:calculationLink link:definitionLink 1002000 - Statement - Consolidated Statements of Operations link:presentationLink link:calculationLink link:definitionLink 1002000 - Statement - Consolidated Statements of Operations link:presentationLink link:calculationLink link:definitionLink 2113100 - Disclosure - Contingencies link:presentationLink link:calculationLink link:definitionLink 0001000 - Document - Document and Entity Information link:presentationLink link:calculationLink link:definitionLink 2106100 - Disclosure - Fair Value Measurements link:presentationLink link:calculationLink link:definitionLink 2406402 - Disclosure - Fair Value Measurements (Details) link:presentationLink link:calculationLink link:definitionLink 2306301 - Disclosure - Fair Value Measurements (Tables) link:presentationLink link:calculationLink link:definitionLink 2112100 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 2412405 - Disclosure - Income Taxes - Components of Deferred Income Taxes (Details) link:presentationLink link:calculationLink link:definitionLink 2412404 - Disclosure - Income Taxes - Effective Income Tax Reconciliation (Details) link:presentationLink link:calculationLink link:definitionLink 2412403 - Disclosure - Income Taxes - Loss from Operations Before Provision for Income Taxes (Details) link:presentationLink link:calculationLink link:definitionLink 2412402 - Disclosure - Income Taxes - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2312301 - Disclosure - Income Taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 2105100 - Disclosure - Loss Per Share link:presentationLink link:calculationLink link:definitionLink 2405402 - Disclosure - Loss Per Share (Details) link:presentationLink link:calculationLink link:definitionLink 2305301 - Disclosure - Loss Per Share (Tables) link:presentationLink link:calculationLink link:definitionLink 2108100 - Disclosure - Operating Leases link:presentationLink link:calculationLink link:definitionLink 2408403 - Disclosure - Operating Leases - Balance Sheet Presentation (Details) link:presentationLink link:calculationLink link:definitionLink 2408404 - Disclosure - Operating Leases - Future Minimum Lease Payments Under Lease Agreements (Details) link:presentationLink link:calculationLink link:definitionLink 2408404 - Disclosure - Operating Leases - Future Minimum Lease Payments Under Lease Agreements (Details) link:presentationLink link:calculationLink link:definitionLink 2408402 - Disclosure - Operating Leases - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2308301 - Disclosure - Operating Leases (Tables) link:presentationLink link:calculationLink link:definitionLink 2104100 - Disclosure - Property and Equipment link:presentationLink link:calculationLink link:definitionLink 2404402 - Disclosure - Property and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 2304301 - Disclosure - Property and Equipment (Tables) link:presentationLink link:calculationLink link:definitionLink 2111100 - Disclosure - Research Funding link:presentationLink link:calculationLink link:definitionLink 2411401 - Disclosure - Research Funding (Details) link:presentationLink link:calculationLink link:definitionLink 2110100 - Disclosure - Share-Based Compensation link:presentationLink link:calculationLink link:definitionLink 2410403 - Disclosure - Share-Based Compensation - Compensation Cost Not Yet Recognized (Details) link:presentationLink link:calculationLink link:definitionLink 2410404 - Disclosure - Share-Based Compensation - Fair Value of Shares Vested and Weighted Average Estimated Fair Value of Shares Granted (Details) link:presentationLink link:calculationLink link:definitionLink 2410402 - Disclosure - Share-Based Compensation - Share-based Compensation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 2310301 - Disclosure - Share-Based Compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 2410405 - Disclosure - Share-Based Compensation - Valuation Assumptions (Details) link:presentationLink link:calculationLink link:definitionLink 2109100 - Disclosure - Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 2409404 - Disclosure - Stockholders' Equity - Activity for Stock Options and Warrants (Details) link:presentationLink link:calculationLink link:definitionLink 2409403 - Disclosure - Stockholders' Equity - Equity Issuances (Details) link:presentationLink link:calculationLink link:definitionLink 2409402 - Disclosure - Stockholders' Equity - Equity Plan (Details) link:presentationLink link:calculationLink link:definitionLink 2409405 - Disclosure - Stockholders' Equity - Restricted Stock and Restricted Stock Units (Details) link:presentationLink link:calculationLink link:definitionLink 2309301 - Disclosure - Stockholders' Equity (Tables) link:presentationLink link:calculationLink link:definitionLink 2114100 - Disclosure - Subsequent Events link:presentationLink link:calculationLink link:definitionLink 2102100 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 2402403 - Disclosure - Summary of Significant Accounting Policies - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2202201 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 2302302 - Disclosure - Summary of Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink