UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                  SCHEDULE 13D
                    Under the Securities Exchange Act of 1934
                               (Amendment No. 2)*


                                  NEOSTEM, INC.
- --------------------------------------------------------------------------------
                                (Name of Issuer)

                    Common Stock, par value $0.001 per share
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)

- --------------------------------------------------------------------------------
                                    640650107
                                 (CUSIP Number)

                                c/o NeoStem, Inc.
                         420 Lexington Avenue, Suite 450
                               New York, NY 10170
                                  212-584-4180

- --------------------------------------------------------------------------------
                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                December 13, 2006
- --------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously filed a statement on Schedule l3G to report
the acquisition that is the subject of this Schedule 13D, and is filing this
schedule because of 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the
following box. |_|

Note: Schedules filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits. See 240.13d-7 for other parties
to whom copies are to be sent.

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).

Cusip No. 640650107 - --------- - -------------------------------------------------------------------------------- 1. Names of Reporting Persons. I.R.S. Identification Nos. of above persons (entities only): Mark Weinreb - -------------------------------------------------------------------------------- 2. Check the Appropriate Box if a Member of a Group (See Instructions): (a) |_| Not (b) |_| Applicable - -------------------------------------------------------------------------------- 3. SEC Use Only - -------------------------------------------------------------------------------- 4. Source of Funds (See Instructions): OO - -------------------------------------------------------------------------------- 5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e): |_| - -------------------------------------------------------------------------------- 6. Citizenship or Place of Organization: United States - -------------------------------------------------------------------------------- Number of 7. Sole Voting Power: 1,234,226* Shares Beneficially -------------------------------------------- Owned by 8. Shared Voting Power: 0 Each Reporting -------------------------------------------- Person With 9. Sole Dispositive Power: 1,234,226* -------------------------------------------- 10. Shared Dispositive Power: 0 -------------------------------------------- - -------------------------------------------------------------------------------- 11 Aggregate Amount Beneficially Owned by Each Reporting Person: 1,234,226* 12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions): |_| - -------------------------------------------------------------------------------- 13. Percent of Class Represented by Amount in Row (11): 5.6%* - -------------------------------------------------------------------------------- 14. Type of Reporting Person (See Instructions): IN - -------------------------------------------------------------------------------- * Includes options to purchase 705,000 shares of common stock, par value $.001 per share (the "Common Stock"), of NeoStem, Inc. (the "Company"); excludes options to purchase 150,000 shares of Common Stock which are not exercisable within sixty days of this Schedule 13D. The numbers also reflect a one-for-ten reverse stock split of the Common Stock that was effective August 31, 2006. -2-

This Amendment No. 2 to Schedule 13D is being filed by the undersigned to amend and supplement the Schedule 13D filed April 29, 2005, as amended, with respect to the shares of common stock, par value $.001 per share (the "Common Stock"), of NeoStem, Inc. Item 1. Security and Issuer Item 1 of this Schedule 13D is amended by deleting the entirety of the text and replacing it with the following: This statement on Schedule 13D (the "Schedule 13D") relates to shares of Common Stock of NeoStem, Inc., a Delaware corporation formerly known as Phase III Medical, Inc. (the "Company"). The principal executive offices of the Company are located at 420 Lexington Avenue, Suite 450, New York, NY 10170. On August 29, 2006, the Company's stockholders approved an amendment to its Certificate of Incorporation to effect a reverse stock split of the Common Stock, at a ratio of one-for-ten shares, and to change the Company's name from Phase III Medical, Inc. to NeoStem, Inc. The reverse stock split was effective as of August 31, 2006. Item 2. Identity and Background Item 2 of this Schedule 13D is amended by deleting the entirety of the text and replacing it with the following: This Schedule 13D is being filed by Mark Weinreb. Mr. Weinreb's principal occupation is President of the Company. Mr. Weinreb's business address and the Company's principal business address is 420 Lexington Avenue, Suite 450, New York, NY 10170. Mr. Weinreb is a citizen of the United States. During the past five years, Mr. Weinreb has not been convicted in a criminal proceeding (excluding traffic violations or similar misdemeanors). During the past five years, Mr. Weinreb has not been a party to a civil proceeding of a judicial or administrative body of competent jurisdiction as a result of which he was or is subject to a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws. Item 3. Source and Amount of Funds or Other Consideration Item 3 of this Schedule 13D is amended by adding at the end thereof the following: On December 5, 2006, the Compensation Committee of the Company's Board of Directors approved a grant to Mr. Weinreb of options to purchase up to 50,000 shares of Common Stock, at an exercise price of $0.60 per share, pursuant to the Company's 2003 Equity Participation Plan. Such options became exercisable on December 13, 2006 based on the achievement of the stated milestone. Item 4. Purpose of Transaction The acquisition of the securities described in Item 3 by Mr. Weinreb is for investment purposes. Mr. Weinreb does not have any present plans or proposals which relate to or would result in the types of events described in clauses (a) through (j) under Item 4 of Schedule 13D. -3-

Item 5. Interest in Securities of the Issuer Item 5 of this Schedule 13D is amended by deleting the entirety of the text and replacing it with the following: Based on information received from the Company, as of December 13, 2006, there were 21,347,215 shares of Common Stock outstanding. As of such date, Mr. Weinreb was the beneficial owner of an aggregate of 1,234,226 shares of Common Stock, or 5.6% of the outstanding shares of Common Stock. Mr. Weinreb has the sole power to vote or to direct the vote and the sole power to dispose or to direct the disposition of all of such shares. Except as described in Item 3 of this Amendment, during the past sixty days, there were no purchases of shares of Common Stock, or securities convertible into or exchangeable for shares of Common Stock, by Mr. Weinreb or any person or entity controlled by Mr. Weinreb or any person or entity for which Mr. Weinreb possesses voting control over the securities thereof. During such sixty day period, there were no sales of the shares of Common Stock, or securities convertible into or exchangeable for shares of Common Stock, by Mr. Weinreb or any person or entity controlled by Mr. Weinreb or any person or entity for which Mr. Weinreb possesses voting control over the securities thereof. -4-

Signature After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. Dated: January 4, 2007 Attention: Intentional misstatements or omissions of fact constitute Federal criminal violations (See 18 U.S.C. 1001). /s/ Mark Weinreb ---------------- Mark Weinreb -5-