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                           June 25, 2020

       Todd Girolamo
       Vice President, General Counsel and Corporate Secretary
       CALADRIUS BIOSCIENCES, INC.
       110 Allen Road, 2nd Floor
       Basking Ridge, NJ 07920

                                                        Re: CALADRIUS
BIOSCIENCES, INC.
                                                            Registration
Statement on Form S-1
                                                            Filed June 19, 2020
                                                            File No. 333-239302

       Dear Mr. Girolamo:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Jason L.
Drory at 202-551-8342 with any questions.




                           Sincerely,


                           Division of Corporation Finance

                           Office of Life Sciences
       cc:                                              Jeffrey P. Schultz