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Document and Entity Information Document - shares	9 Months Ended
Document and Entity Information Document - shares	Sep. 30, 2016	Nov. 01, 2016
Document Information [Line Items]
Entity Registrant Name	Caladrius Biosciences, Inc.
Entity Central Index Key	0000320017
Current Fiscal Year End Date	--09-30
Entity Filer Category	Accelerated Filer
Document Type	10-Q
Document Period End Date	Sep. 30, 2016
Document Fiscal Year Focus	2016
Document Fiscal Period Focus	Q3
Amendment Flag	false
Entity Common Stock, Shares Outstanding		8,169,407

Consolidated Balance Sheets - USD ($)	Sep. 30, 2016	Dec. 31, 2015
Current Assets
Cash and cash equivalents	$ 18,606,743	$ 20,318,411
Accounts receivable, net of allowances of $572,500 at September 30, 2016 and $0 at December 31, 2015	4,274,800	2,566,101
Deferred costs	4,315,977	2,911,743
Prepaid expenses and other current assets	2,767,243	3,476,177
Total current assets	29,964,763	29,272,432
Property, plant and equipment, net	17,123,693	17,064,900
Goodwill	7,013,315	7,013,315
Intangible assets, net	2,450,380	2,877,880
Other assets	726,787	976,768
Total assets	57,278,938	57,205,295
Current Liabilities
Accounts payable	3,245,779	4,107,388
Accrued liabilities	6,372,789	6,198,488
Long-term debt, current	2,319,844	4,171,456
Notes payable, current	745,234	1,192,666
Unearned revenues	5,869,586	5,345,225
Total current liabilities	18,553,232	21,015,223
Long-term Liabilities
Deferred income taxes	1,079,948	932,662
Notes payable	224,722	583,041
Unearned revenues - long-term	4,329,950	0
Long-term debt	3,331,510	10,828,544
Other long-term liabilities	370,081	562,001
Total liabilities	27,889,443	33,921,471
Commitments and Contingencies (see Note 15)
Redeemable Securities	19,400,000	0
Stockholders' Equity
Preferred stock, authorized, 20,000,000 shares Series B convertible redeemable preferred stock liquidation value, 1 share of common stock, $.01 par value; 825,000 shares designated; issued and outstanding, 10,000 shares at September 30, 2016 and December 31, 2015	100	100
Common stock, $.001 par value, authorized 500,000,000 shares; issued and outstanding, 8,181,921 and 5,673,302 shares, at September 30, 2016 and December 31, 2015, respectively	8,182	5,673
Additional paid-in capital	410,276,001	396,547,401
Treasury stock, at cost; 10,999 shares at September 30, 2016 and December 31, 2015, respectively	(707,637)	(707,637)
Accumulated deficit	(398,830,656)	(372,132,490)
Accumulated other comprehensive income	0	486
Total Caladrius Biosciences, Inc. stockholders' equity	10,745,990	23,713,533
Noncontrolling interests	(756,495)	(429,709)
Total equity	9,989,495	23,283,824
Liabilities and Equity, Total	$ 57,278,938	$ 57,205,295

Consolidated Balance Sheets (Parentheticals) - USD ($)	Sep. 30, 2016	Dec. 31, 2015
Statement of Financial Position [Abstract]
Preferred Stock, Shares Outstanding	10,000	10,000
Common Stock, Par Value	$ 0.001	$ 0.001
Accounts receivable trade, net of allowance for doubtful accounts	$ 572,500	$ 0
Preferred Stock, authorized	20,000,000	20,000,000
Common Stock, Shares, Outstanding	8,181,921	5,673,302
Common Stock, Shares Authorized	500,000,000	500,000,000
Common Stock, Shares, Issued	8,181,921	5,673,302
Preferred stock, shares designated	825,000	825,000
Preferred stock, issued	10,000	10,000
Preferred stock, Series B convertible redeemable preferred stock liquidation value, share of common stock	0.01	0.01
Preferred stock, par value	$ 0.01	$ 0.01
Treasury stock (shares)	10,999	10,999

Consolidated Statements of Operations - USD ($)	3 Months Ended		9 Months Ended
Consolidated Statements of Operations - USD ($)	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Revenues	$ 9,317,473	$ 5,888,450	$ 25,107,391	$ 14,927,691
Cost of revenues	8,611,208	4,808,679	21,891,010	13,976,087
Research and development	2,630,632	6,315,613	12,534,775	20,719,989
Impairment of intangible assets	0	0	0	9,400,000
Selling, general, and administrative	4,936,486	5,147,166	16,100,696	24,971,438
Total operating costs and expenses	16,178,326	16,271,458	50,526,481	69,067,514
Operating loss	(6,860,853)	(10,383,008)	(25,419,090)	(54,139,823)
Other income (expense):
Other income (expense), net	5,117	(410,233)	17,662	4,398,585
Interest expense	(384,915)	(552,983)	(1,671,457)	(1,651,222)
Nonoperating Income (Expense), Total	(379,798)	(963,216)	(1,653,795)	2,747,363
Loss before provision for income taxes and noncontrolling interests	(7,240,651)	(11,346,224)	(27,072,885)	(51,392,460)
Provision (benefit) for income taxes	46,954	46,633	147,286	(3,610,097)
Net loss	(7,287,605)	(11,392,857)	(27,220,171)	(47,782,363)
Less - loss attributable to noncontrolling interests	(405,072)	(16,907)	(522,005)	(93,257)
Net loss attributable to Caladrius Biosciences, Inc. common stockholders	$ (6,882,533)	$ (11,375,950)	$ (26,698,166)	$ (47,689,106)
Basic and diluted loss per share attributable to Caladrius Biosciences, Inc. common stockholders	$ (1.09)	$ (2.06)	$ (4.45)	$ (10.40)
Weighted average common shares outstanding	6,323,427	5,523,912	6,001,572	4,586,757
Available for sale securities - net unrealized (loss) gain	$ 0	$ (988)	$ (486)	$ (451)
Total other comprehensive loss	0	(988)	(486)	(451)
Comprehensive loss	(7,287,605)	(11,393,845)	(27,220,657)	(47,782,814)
Comprehensive loss attributable to noncontrolling interests	(405,072)	(16,908)	(522,005)	(93,257)
Comprehensive loss attributable to Caladrius Biosciences, Inc. common stockholders	$ (6,882,533)	$ (11,376,937)	$ (26,698,652)	$ (47,689,557)

Consolidated Statements of Comprehensive Loss - USD ($)	3 Months Ended		9 Months Ended
Consolidated Statements of Comprehensive Loss - USD ($)	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Net loss	$ (7,287,605)	$ (11,392,857)	$ (27,220,171)	$ (47,782,363)
Available for sale securities - net unrealized (loss) gain	0	(988)	(486)	(451)
Total other comprehensive loss	0	(988)	(486)	(451)
Comprehensive loss	(7,287,605)	(11,393,845)	(27,220,657)	(47,782,814)
Comprehensive loss attributable to noncontrolling interests	(405,072)	(16,908)	(522,005)	(93,257)
Comprehensive loss attributable to Caladrius Biosciences, Inc. common stockholders	$ (6,882,533)	$ (11,376,937)	$ (26,698,652)	$ (47,689,557)

Consolidated Statements of Equity - USD ($)	Total	Total NeoStem, Inc. Shareholders' Equity [Member]	Series B Convertible Preferred Stock Series B Convertible Preferred Stock	Common Stock	Additional Paid in Capital	Accumulated Other Comprehensive Income	Accumulated Deficit	Treasury Stock	Non- Controlling Interest in Subsidiary
Beginning Balance (shares) at Dec. 31, 2014			10,000	3,678,386
Beginning Balance at Dec. 31, 2014	$ 58,073,789	$ 58,514,836	$ 100	$ 3,678	$ 350,462,009	$ 1,329	$ (291,246,538)	$ (705,742)	$ (441,047)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(47,782,363)	(47,689,106)					(47,689,106)		(93,257)
Unrealized gain/loss on marketable securities	(451)	(451)
Share-based compensation (in shares)				81,184
Share-based compensation	8,568,605	8,568,605		$ 81	8,568,524
Proceeds from issuance of common stock (in shares)				1,790,155
Net proceeds from issuance of common stock	36,136,839	36,136,839		$ 1,790	36,135,049
Change in Ownership in Subsidiary	0	(101,367)			(101,367)				101,367
Ending Balance at Sep. 30, 2015	54,996,419	55,429,356	$ 100	$ 5,549	395,064,215	878	(338,935,644)	(705,742)	(432,937)
Ending Balance (shares) at Sep. 30, 2015			10,000	5,549,725
Beginning Balance (shares) at Dec. 31, 2015			10,000	5,673,302
Beginning Balance at Dec. 31, 2015	23,283,824	23,713,533	$ 100	$ 5,673	396,547,401	486	(372,132,490)	(707,637)	(429,709)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(27,220,171)	(26,698,166)					(26,698,166)		(522,005)
Unrealized gain/loss on marketable securities	(486)	(486)				(486)
Share-based compensation (in shares)				104,754
Share-based compensation	2,275,616	2,275,616		$ 105	2,275,511
Proceeds from issuance of common stock (in shares)				2,403,865
Net proceeds from issuance of common stock	11,650,712	11,650,712		$ 2,404	11,648,308
Change in Ownership in Subsidiary	0	(195,219)			(195,219)				195,219
Ending Balance at Sep. 30, 2016	$ 9,989,495	$ 10,745,990	$ 100	$ 8,182	$ 410,276,001	$ 0	$ (398,830,656)	$ (707,637)	$ (756,495)
Ending Balance (shares) at Sep. 30, 2016			10,000	8,181,921

Consolidated Statements of Cash Flows - USD ($)	9 Months Ended
Consolidated Statements of Cash Flows - USD ($)	Sep. 30, 2016	Sep. 30, 2015
Cash flows from operating activities:
Net loss	$ (27,220,171)	$ (47,782,363)
Adjustments to reconcile net loss to net cash used in operating activities:
Equity-based compensation expense	2,275,616	8,568,605
Depreciation and amortization	2,093,153	1,893,028
Change in acquisition-related contingent consideration	0	(4,380,000)
Impairment of intangible assets	0	9,400,000
Loss on disposal of assets	591,307	0
Bad debt recovery	0	(3,774)
Deferred income taxes	147,286	(3,610,097)
Accretion on marketable securities	0	77,577
Changes in operating assets and liabilities:
Prepaid expenses and other current assets	708,935	908,011
Accounts receivable	(1,708,699)	815,231
Deferred costs	(1,404,234)	(781,629)
Unearned revenues	4,854,312	1,163,954
Other assets	249,493	53,743
Accounts payable, accrued liabilities and other liabilities	(879,228)	3,147,091
Net cash used in operating activities	(20,292,230)	(30,530,623)
Cash flows from investing activities:
Purchase of marketable securities	0	(6,081,900)
Sale of marketable securities	0	7,734,528
Acquisition of property, plant and equipment	(2,315,753)	(2,573,784)
Net cash used in investing activities	(2,315,753)	(921,156)
Cash flows from financing activities:
Net proceeds from issuance of common stock	11,650,712	36,136,839
Repayment of long-term debt	(9,348,646)	0
Proceeds from notes payable	368,615	1,087,361
Repayment of notes payable	(1,174,366)	(903,783)
Sale of ownership interest in subsidiary	19,400,000	0
Net cash provided by financing activities	20,896,315	36,320,417
Net (decrease) increase in cash and cash equivalents	(1,711,668)	4,868,638
Cash and cash equivalents at beginning of period	20,318,411	19,174,061
Cash and cash equivalents at end of period	18,606,743	24,042,699
Cash paid during the period for:
Interest	$ 1,679,880	$ 1,122,479

The Business

9 Months Ended

Sep. 30, 2016

The Business [Abstract]

The Business

Overview

Caladrius Biosciences, Inc. (“we,” “us,” "our," “Caladrius” or the “Company”), through its subsidiary, PCT, LLC, a Caladrius Company^TM("PCT"), is a leading provider of development and manufacturing services to the cell and cell-based gene therapy industry. PCT has significant cell therapy-specific experience and expertise, an expansive list of noteworthy clients and significant revenue growth over the past two years. Notably, PCT and Hitachi Chemical Co. America, Ltd. and Hitachi Chemical Co., Ltd. (each independently or collectively referred to herein as "Hitachi Chemical") are engaged in a strategic collaboration to accelerate the creation of a global commercial cell therapy development and manufacturing enterprise with deep engineering expertise. Caladrius leverages both its internal specialized cell therapy clinical development expertise and PCT’s prowess to select and develop early-stage cell therapy candidates with the intention of partnering these candidates post proof-of-concept in man to both generate value for our shareholders and to expand PCT’s client base. Our current lead product candidate, CLBS03, is a T regulatory cell (“Treg”) clinical Phase 2 therapy targeting adolescents with recent-onset type 1 diabetes.

Cell Therapy Development and Manufacturing

PCT is a leading cell therapy development and manufacturing provider (often called a contract development and manufacturing organization, or "CDMO"), specializing in cell and cell-based gene therapies. PCT offers high-quality development and manufacturing capabilities (e.g., current Good Manufacturing Practice (“cGMP”) manufacturing systems and facilities), quality systems, cell and tissue processing, logistics, storage and distribution and engineering solutions (e.g., process and assay development, optimization and automation) to clients with therapeutic candidates at all stages of development. PCT produces clinical supplies and ultimately, intends also to produce commercial product for its clients. PCT has worked with over 100 clients and produced over 20,000 cell therapy products since it was founded 17 years ago. PCT’s manufacturing services are designed to reduce the capital investment and time required by clients to advance their development programs compared to conducting the process development and manufacturing in-house. PCT has demonstrated regulatory expertise, including the support of over 50 U.S. and European Union ("EU") regulatory filings for clients and expertise across multiple cell types and therapeutic applications, including immunotherapy (e.g. CAR-T therapies), neuro/endocrine therapies, hematopoietic replacement and tissue repair/regeneration. PCT offers a complete development pathway for its clients, with services supporting preclinical through commercial phase, all underpinned by timely process optimization and automation support. We currently operate facilities qualified under cGMPs in each of Allendale, New Jersey and Mountain View, California, including EU-grade production suites. On March 11, 2016, PCT entered into a strategic collaboration and license agreement with Hitachi Chemical to accelerate the creation of a global commercial cell therapy development and manufacturing enterprise with deep engineering expertise. PCT is positioned to expand its capacity both in the United States and internationally, as needed. As the industry continues to mature and a growing number of cell therapy companies approach commercialization, we believe that PCT is well positioned to serve as an external manufacturing partner of choice for commercial-stage cell therapy companies.

CLBS03

We are developing, through the utilization of our core development and manufacturing expertise, a product candidate that is an innovative therapy for type 1 diabetes mellitus ("TID"). This therapy is based on a proprietary platform technology for immunomodulation. We have selected as an initial target the unmet medical need of pediatric patients who are newly diagnosed with T1D. This program is based on the use of Tregs to treat diseases caused by imbalances in an individual's immune system. This novel approach seeks to restore immune balance by enhancing Treg number and function. Tregs are a natural part of the human immune system and regulate the activity of T effector cells; the cells that are responsible for protecting the body from viruses and other foreign antigens. When Tregs function properly, only harmful foreign materials are attacked by T effector cells. In autoimmune disease, however, it is thought that deficient Treg activity and numbers permit the T effector cells to attack the body's own beneficial cells. In the case of T1D, there are currently no curative treatments, only lifelong insulin therapy, which often does not prevent serious co-morbidities. Two Phase 1 clinical trials of this technology in T1D patients demonstrated safety and tolerance, feasibility of manufacturing, an implied durability of effect and an early indication of efficacy through the preservation of beta cell function. In the first quarter of 2016, we commenced patient enrollment in the first of two cohorts in The Sanford Project: T-Rex Study, a Phase 2 prospective, randomized, placebo-controlled, double-blind clinical trial to evaluate the safety and efficacy of our Treg product candidate, CLBS03, in adolescents with recent onset T1D. In August 2016, we completed enrollment of the first 19 patients, and after a satisfactory evaluation of the safety of this initial cohort by our independent Data Safety Monitoring Board, we resumed the enrollment of the remaining 92 patients. A subsequent interim analysis of early therapeutic effect is planned after approximately 50% of patients reach the six-month follow-up milestone. We entered into a strategic collaboration with Sanford Research to support the execution of this trial. Sanford Research is a U.S.-based non-profit research organization that supports an emerging translational research center focused on finding a cure for T1D. CLBS03 has been granted Fast Track and Orphan Drug designations from the FDA as well as Advanced Therapeutic Medicinal Product classification from the European Medicines Agency.

Additional Technology Platforms

Our broad intellectual property portfolio of cell therapy assets includes notable programs available for out-licensing and partnering in order to continue our clinical development. These include platforms using CD34 technology for ischemic repair and tumor cell/dendritic cell technology for immuno-oncology. Both have the benefit of promising Phase 2 clinical data and are applicable to multiple indications. With respect to our ischemic repair platform, the Company's Clinical Trial Notification for a pivotal Phase 2 trial investigating CLBS12 (a candidate for critical limb ischemia, or "CLI") was submitted to the Japanese Pharmaceuticals and Medical Devices Agency ("PMDA") and was cleared to proceed. The protocol design was agreed with PMDA and if successful, could provide the basis for a conditional approval under Japan's favorable regenerative medicine law. We are seeking to collaborate on CLBS12 with development and/or manufacturing partners. In January 2016, we out-licensed our CD34 technology to SPS Cardio, LLC for chronic heart failure and acute myocardial infarction (candidate CLBS10) in India and other designated territories and non-major world markets outside the United States. The immuno-oncology platform is based on our extensive intellectual property portfolio and includes CLBS20, a candidate for metastatic melanoma which was investigated in two Phase 2 trials and recently in a discontinued Phase 3 clinical trial. In February 2016, we out-licensed a cell-derived dermatological product technology for topical skin application to AiVita Biomedical, Inc. ("AiVita"), which product is distributed through ALPHAEON Corporation. Furthermore, in May 2016, we out-licensed our tumor cell/dendritic cell technology to AiVita for ovarian cancer (candidate CLBS23) for worldwide use. Finally, our Treg immune modulation platform has potential applications across multiple autoimmune and allergic diseases beyond TID for which we are exploring partnering opportunities, including steroid-resistant asthma, multiple sclerosis, chronic obstructive pulmonary disease, inflammatory bowel disease, graft versus host disease, lupus and rheumatoid arthritis.

Our long-term strategy focuses on advancing cell-based therapies to the market and assisting patients suffering from life-threatening medical conditions. Coupling our clinical development expertise with our process development and manufacturing capabilities, we believe we are positioned to realize potentially meaningful value increases within our own proprietary pipeline based on demonstration of proof-of-concept in man as well as process and manufacturing advancements.

Financial Information & Liquidity

On March 11, 2016, PCT and Caladrius entered into a global licensing, development and equity collaboration with Hitachi Chemical, a Japanese-based global conglomerate with a growing franchise in life sciences including regenerative medicine ("Hitachi Transaction"), including a commitment to receive an aggregate of $25.0 million in cash, of which $22.5 million was received in March 2016, $1.25 million was received in June 2016, and the remainder is expected to be received before the end of 2016. PCT will retain $10.0 million of the $25.0 million proceeds, and Caladrius received $15.0 million of the proceeds. Concurrent with the Hitachi Transaction, Caladrius used $7.0 million of the proceeds to repay a portion of its outstanding loan with Oxford Finance.

On September 14, 2016, the Company entered into a securities purchase agreement with a single institutional investor (the “Purchaser”), pursuant to which the Company issued and sold to the Purchaser, in a registered direct offering, an aggregate of 0.8 million shares of the Company’s common stock at a purchase price of $4.72 per share. The gross proceeds to the Company from the registered direct offering of the shares of common stock were $4.0 million.

In concurrent private placements, on September 14, 2016, the Company entered into Securities Purchase Agreements (each a “Private Placement Purchase Agreement” and, collectively, the “Private Placement Purchase Agreements”) with certain accredited investors (the “Investors”) with whom it had a substantive, pre-existing relationship, including certain existing stockholders, for the sale by the Company of an aggregate of 4.4 million shares of its common stock, at a purchase price of $4.72 per share. The investments will be placed in two tranches: (i) $12.6 million upon an initial closing (the “Initial Closing”), and (ii) $8.4 million, subject to certain conditions, including the enrollment of 70 subjects in the Company’s Phase 2 CLBS03 clinical trial, in a second closing (the “Second Closing”). As of September 30, 2016, $6.6 million of the Initial Closing tranche was received, and 1.4 million shares of common stock had been issued. Based on management's expectations, the remaining $6.0 million of the Initial Closing tranche is expected to be received in the fourth quarter of 2016, and 1.3 million shares of common stock will then be issued.

In September 2016, the Company used $3.0 million of the proceeds to repay a portion of its outstanding loan from Oxford Finance.

The Company anticipates requiring additional capital in order to grow the PCT business, to fund the development of CLBS03, to fund other operating expenses and to make principal and interest payments on the loan with Oxford Finance. To meet its short and long term liquidity needs, the Company currently expects to use existing cash and cash equivalents balances, additional cash to be raised through the Private Placement Purchase Agreements, revenue generating activities and a variety of other means, including its common stock purchase agreements with Aspire Capital. Other sources of liquidity could include additional potential issuances of debt or equity securities in public or private financings, partnerships and/or collaborations and/or sale of assets. In addition, the Company will continue to seek appropriate grants for scientific and clinical studies from various governmental agencies and foundations. While the Company continues to seek capital through a number of means, there can be no assurance that additional financing will be available on acceptable terms, if at all. If the Company is unable to access capital necessary to meet its long-term liquidity needs, it may have to delay or discontinue the development of CLBS03 and/or the expansion of its business or raise funds on terms that the Company currently consider unfavorable. The Company's inability to raise additional capital would also raise substantial doubt about the Company's ability to continue as a going concern for a reasonable period of time. These unaudited consolidated financial statements have been prepared on a going concern basis and, as such, do not include any adjustments that might result from the outcome of this uncertainty that might be necessary should the Company be unable to continue as a going concern.

On July 28, 2016, the Company implemented a one-for-ten reverse split of its issued and outstanding shares of common stock (the “Reverse Stock Split”), as authorized at the annual meeting of stockholders on June 22, 2016. The Reverse Stock Split became effective on July 27, 2016 at 5:00 pm and the common stock of the Company began trading on The NASDAQ Capital Market on a post-split basis at the open of business on July 28, 2016. As of July 28, 2016, every ten shares of the Company’s issued and outstanding common stock were combined into one share of its common stock, except to the extent that the Reverse Stock Split resulted in any of the Company’s stockholders owning a fractional share, which was rounded up to the next highest whole share. In connection with the Reverse Stock Split, there was no change in the nominal par value per share of $0.001. The Reverse Stock Split was effectuated in order to increase the per share trading price of the Company’s common stock to satisfy the $1.00 minimum bid price requirement for continued listing on The NASDAQ Capital Market. By letter dated August 11, 2016, The NASDAQ Capital Market, Listing Qualification Department, confirmed that the Company's common stock was in compliance with listing requirements.

All share and per share amounts of common stock, options and warrants in the accompanying financial statements have been restated for all periods to give retroactive effect to the Reverse Stock Split. Accordingly, the consolidated statements of equity reflect the impact of the Reverse Stock Split by reclassifying from “common stock” to “Additional paid-in capital” in an amount equal to the par value of the decreased shares resulting from the Reverse Stock Split.

Basis of Presentation

The accompanying unaudited Consolidated Financial Statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“GAAP”) for interim financial information and with the instructions to Form 10-Q and Article 10 of Regulation S-X of the SEC for interim financial information. Accordingly, they do not include all of the information and footnotes required by generally accepted accounting principles for complete financial statements. In the opinion of management, the accompanying Consolidated Financial Statements of the Company and its subsidiaries, which are unaudited, include all normal and recurring adjustments considered necessary to present fairly the Company’s financial position as of September 30, 2016 and the results of its operations and its cash flows for the periods presented. The unaudited consolidated financial statements herein should be read together with the historical consolidated financial statements of the Company for the years ended December 31, 2015, 2014 and 2013 included in our 2015 Form 10-K. Operating results for the nine months ended September 30, 2016 are not necessarily indicative of the results that may be expected for the year ending December 31, 2016.

Use of Estimates

The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the consolidated financial statements. Estimates also affect the reported amounts of revenues and expenses during the reporting period. The Company bases its estimates on historical experience and other assumptions believed to be reasonable under the circumstances, the results of which form the basis for making judgments about the carrying value of assets and liabilities that are not readily apparent from other sources. The Company makes critical estimates and assumptions in determining the fair values of goodwill for potential goodwill impairments, useful lives of our tangible long lived assets, allowances for doubtful accounts, and stock-based awards values. Accordingly, actual results could differ from those estimates and assumptions.

An accounting policy is considered to be critical if it is important to the Company’s financial condition and results of operations and if it requires management’s most difficult, subjective and complex judgments in its application.

Principles of Consolidation

The Consolidated Financial Statements include the accounts of Caladrius Biosciences, Inc. and its wholly-owned and partially-owned subsidiaries and affiliates as listed below. All intercompany activities have been eliminated in consolidation.



Entity	Percentage of Ownership	Location
Caladrius Biosciences, Inc.	100%	United States of America
Amorcyte, LLC	100%	United States of America
PCT, LLC, a Caladrius Company (1)	80.1%	United States of America
NeoStem Family Storage, LLC (1)	80.1%	United States of America
Athelos Corporation (2)	98.2%	United States of America
PCT Allendale, LLC (1)	80.1%	United States of America
NeoStem Oncology, LLC	100%	United States of America

_________________________________________________________________

(1) As of September 30, 2016, Hitachi's ownership interest was 19.9% (see Note 3).

(2) As of September 30, 2016, Becton Dickinson's ownership interest was 1.8%.

Summary of Significant Accounting Policies

9 Months Ended

Sep. 30, 2016

Summary of Significant Accounting Policies [Abstract]

Summary of Significant Accounting Policies

In addition to the policies below, our significant accounting policies are described in Note 2 of the Notes to Consolidated Financial Statements included in our 2015 Form 10-K. There were no changes to these policies during the nine months ended September 30, 2016.

Concentration of Risks

We are subject to credit risk from our portfolio of cash and cash equivalents and marketable securities. Under our investment policy, we limit amounts invested in such securities by credit rating, maturity, industry group, investment type and issuer, except for securities issued by the U.S. government. Cash is held at major banks in the United States. Therefore, the Company is not exposed to any significant concentrations of credit risk from these financial instruments. The goals of our investment policy, in order of priority, are as follows: safety and preservation of principal and diversification of risk; liquidity of investments sufficient to meet cash flow requirements, and a competitive after-tax rate of return.

We are also subject to credit risk from our accounts receivable related to our services. The majority of our trade accounts receivable arises from services in the United States.

For the nine months ended September 30, 2016, the 3 largest customers represented 43% of total revenues recognized, the largest of which was 18%. As of September 30, 2016, 3 customers represented 37% of our accounts receivable, the largest of which was 15%.

Share-Based Compensation

The Company expenses all share-based payment awards to employees, directors, consultants, including grants of stock options, warrants, and restricted stock, over the requisite service period based on the grant date fair value of the awards. Consultant awards are remeasured each reporting period through vesting. For awards with performance-based vesting criteria, the Company estimates the probability of achievement of the performance criteria and recognizes compensation expense related to those awards expected to vest. The Company determines the fair value of option awards using the Black-Scholes option-pricing model which uses both historical and current market data to estimate the fair value. This method incorporates various assumptions such as the risk-free interest rate, expected volatility, expected dividend yield and expected life of the options or warrants. The fair value of the Company’s restricted stock and restricted stock units is based on the closing market price of the Company’s common stock on the date of grant.

Goodwill

Goodwill is the excess of purchase price over the fair value of identified net assets of businesses acquired. The Company reviews goodwill at least annually, or at the time a triggering event is identified for possible impairment. Goodwill is reviewed for possible impairment between annual tests if an event occurs or circumstances change that would more likely than not reduce the fair value of the reporting unit below its carrying value. The Company tests its goodwill each year on December 31. The Company reviews the carrying value of goodwill utilizing an income approach model, and, where appropriate, a market value approach is also utilized to supplement the discounted cash flow model. The Company makes assumptions regarding estimated future cash flows, discount rates, long-term growth rates and market values to determine each reporting unit’s estimated fair value. If these estimates or related assumptions change in the future, the Company may be required to record impairment charges. In accordance with its accounting policy, the Company tested goodwill for impairment as of December 31, 2015 and June 30, 2015 and determined as of December 31, 2015 goodwill valued at $18.2 million related to the Company's Research and Development reporting unit was impaired.

Definite-Lived Intangible Assets

Definite-lived intangible assets consist of customer lists, manufacturing technology, tradenames, patents and rights. These intangible assets are amortized on a straight line basis over their respective useful lives. The Company reviews definite-lived intangible assets for impairment whenever events or changes in circumstances indicate that the carrying amount of an asset exceeds the fair value of the asset. If other events or changes in circumstances indicate that the carrying amount of an asset that the Company expects to hold and use may not be recoverable, the Company will estimate the undiscounted future cash flows expected to result from the use of the asset and/or its eventual disposition, and recognize an impairment loss, if any. The impairment loss, if determined to be necessary, would be measured as the amount by which the carrying amount of the assets exceeds the fair value of the assets. No triggering events were noted in the quarter ended September 30, 2016 that would require interim impairment assessment.

Revenue Recognition

Clinical Services: The Company recognizes revenue for its (i) process development and (ii) clinical manufacturing services based on the terms of individual contracts.

We recognize revenues when all of the following conditions are met:


•	persuasive evidence of an arrangement exists;


•	delivery has occurred or the services have been rendered;


•	the fee is fixed or determinable; and


•	collection is probable.

The Company considers signed contracts as evidence of an arrangement. The Company assesses whether the fee is fixed or determinable based on the payment terms associated with the transaction and whether the payment terms are subject to refund or adjustment. The Company assesses cash collectability based on a number of factors, including past collection history with the client and the client's creditworthiness. If the Company determines that collectability is not reasonably assured, it defers revenue recognition until collectability becomes reasonably assured, which is generally upon receipt of the cash. The Company's arrangements are generally non-cancellable, though clients typically have the right to terminate their agreement for cause if the Company materially fails to perform.

Revenues associated with process development services generally contain multiple stages that do not have stand-alone values and are dependent upon one another, and are recognized as revenue on a completed contract basis. Progress billings collected prior to contract completion are recorded as unearned revenue until such time the contract is completed, which usually requires formal client acceptance.

Clinical manufacturing services are generally distinct arrangements whereby the Company is paid for time and materials or for fixed monthly amounts. Revenue is recognized when contractual terms have been met.

Some client agreements include multiple elements, comprised of cell process development and cell manufacturing services. The Company believes that process development and clinical manufacturing services each have stand-alone value because these services can be provided separately by other companies. In accordance with ASC Update No. 2009-13, “Revenue Recognition (Topic 605): Multiple-Deliverable Revenue Arrangements,” the Company (1) separates deliverables into separate units of accounting when deliverables are sold in a bundled arrangement and (2) allocates the arrangement's consideration to each unit in the arrangement based on its relative selling price.

Clinical Services Reimbursements: The Company separately charges the customers for the expenses associated with certain consumable resources (reimbursable expenses) that are specified in each clinical services contract. On a monthly basis, the Company bills customers for reimbursable expenses and immediately recognizes these billings as revenue, as the revenue is deemed earned as reimbursable expenses are incurred. For the three months ended September 30, 2016 and 2015, clinical services reimbursements were $1.6 million and $0.9 million, respectively. For the nine months ended September 30, 2016 and 2015, clinical services reimbursements were $5.0 million and $2.3 million, respectively.

Processing and Storage Services: The Company recognizes revenue related to the collection and cryopreservation of autologous adult stem cells when the cryopreservation process is completed which is approximately twenty-four hours after cells have been collected. Revenue related to advance payments of storage fees is recognized ratably over the period covered by the advance payments.

License Fees: PCT and Hitachi Chemical also entered into an exclusive license agreement for Asia pursuant to which PCT will receive $5.6 million from Hitachi Chemical in three fee driven payments throughout 2016. PCT licensed to Hitachi Chemical certain cell therapy technology and know-how (including an exclusive license to use the PCT brand in Asia) and agreed to provide Hitachi Chemical with certain training and support. As additional consideration, Hitachi Chemical will pay PCT royalties on contract revenue generated in Asia for a minimum of ten years. The initial term of the License Agreement is ten years and may be automatically extended for successive additional two year terms. The Company recognizes the payments as revenue on a straight-line basis over the initial ten-year term. PCT has received $4.4 million under the Technology License Agreement through September 30, 2016. For the three and nine months ended September 30, 2016, the Company recognized $0.11 million and $0.2 million of license fee revenue, respectively. As of September 30, 2016, $0.4 million of Hitachi license fees were included in unearned revenue, and $4.3 million was included in unearned revenue - long-term.

Recently Issued Accounting Pronouncement

In May 2014, the FASB issued Accounting Standards Update ("ASU") 2014-09, "Revenue from Contracts with Customers (Topic 606)." The new revenue recognition standard provides a five-step analysis to determine when and how revenue is recognized. The standard requires that a company recognizes revenue to depict the transfer of promised goods or services to customers in an amount that reflects the consideration to which the company expects to be entitled in exchange for those goods or services. This ASU is effective for annual periods beginning after December 15, 2017 and will be applied retrospectively to each period presented or as a cumulative-effect adjustment as of the date of adoption. The Company is currently evaluating the impact of the pending adoption of ASU 2014-09 on its consolidated financial statements.

In February 2016, the FASB issued ASU 2016-02, Leases (Topic 842). This ASU requires that a lessee recognize lease assets and lease liabilities for those leases classified as operating leases. The guidance is effective for interim and annual periods beginning after December 15, 2018, and will be applied at the beginning of the earliest period presented using a modified retrospective approach. This ASU may have a material impact on the Company’s financial statements. The impact on the Company’s results of operations is currently being evaluated. The impact of the ASU is non-cash in nature and will not affect the Company’s cash position.

In March 2016, the FASB issued ASU 2016-09, Improvements to Employee Share-Based Payment Accounting. This ASU simplifies several aspects of the accounting for share-based payment transactions, including the income tax consequences, accounting for forfeitures, classification of awards as either equity or liabilities, and classification on the statement of cash flows. The guidance is effective for interim and annual periods beginning after December 15, 2016, with early adoption permitted. The guidance will be applied prospectively, retrospectively, or by means of a cumulative-effect adjustment to equity as of the beginning of the period in which the guidance is adopted, dependent upon the specific amendment that is adopted within the ASU. The Company is currently evaluating the effect that adopting this new guidance will have on the consolidated results of operations, cash flows, and financial position.

In August 2016, the FASB issued ASU 2016-15, Statement of Cash Flows (Topic 230): Classification of Certain Cash Receipts and Cash Payments. ASU 2016-15 clarifies how companies present and classify certain cash receipts and cash payments in the statement of cash flows where diversity in practice exists. ASU 2016-15 is effective in first quarter of fiscal 2018 and earlier adoption is permitted. The Company is currently evaluating the effect that the updated standard will have on the consolidated financial statements and related disclosures.

In October 2016, the FASB issued ASU 2016-16, Intra-Entity Transfers of Assets Other Than Inventory. ASU 2016-16 requires the income tax consequences of intra-entity transfers of assets other than inventory to be recognized as current period income tax expense or benefit at the transaction date and removes the option to defer and amortize the consolidated tax consequences of intra-entity transfers. The new standard will be effective on January 1, 2018 and will be adopted using a modified retrospective approach which requires a cumulative effect adjustment to retained earnings as of the beginning of the period of adoption. Early adoption is permitted at the beginning of a fiscal year. The Company is currently evaluating the effect that the updated standard will have on the consolidated financial statements and related disclosures.

Collaboration and License Agreement	9 Months Ended
Collaboration and License Agreement	Sep. 30, 2016
Business Combinations [Abstract]
Collaboration and License Agreement	Collaboration and License Agreement Hitachi On March 11, 2016, PCT entered into a global collaboration that includes licensing, development and equity components with Hitachi Chemical to develop our PCT business outside of the United States. This collaboration consists of an equity investment in and a license agreement with PCT. Under the equity investment agreement, Hitachi Chemical purchased a 19.9% membership interest in PCT for $19.4 million of which $15.0 million of proceeds was distributed to Caladrius from PCT and $4.4 million remained at PCT to be used for the continued expansion and improvements at PCT in support of commercial product launch readiness as well as for general corporate purposes. Caladrius remains the majority shareholder retaining an 80.1% ownership interest. PCT and Hitachi Chemical also entered into an exclusive license agreement for the acceleration of the creation of a global commercial cell therapy development and manufacturing expertise in Asia pursuant to which PCT will receive $5.6 million from Hitachi Chemical in three fee-driven payments throughout 2016, $4.4 million of which has been received as of September 30, 2016 and the remainder of which is expected to be received before the end of 2016. PCT licensed certain cell therapy technology and know-how (including an exclusive license in Asia) and agreed to provide Hitachi Chemical with certain training and support. As additional consideration, Hitachi Chemical will pay PCT royalties on contract revenue generated in Asia for a minimum of ten years. Lastly, as part of the transaction, PCT and Hitachi Chemical agreed to explore the possibility of pursuing a collaboration in cell therapy contract development and manufacturing in Europe.

Available-for-Sale-Securities

9 Months Ended

Sep. 30, 2016

Available-for-sale Securities [Abstract]

Cash, Cash Equivalents, and Marketable Securities [Text Block]

Available-for-Sale-Securities

The following table is a summary of available-for-sale securities recorded in cash and cash equivalents or marketable securities in our Consolidated Balance Sheets (in thousands):



	September 30, 2016									December 31, 2015
	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Estimated Fair Value		Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses		Estimated Fair Value
Certificate of deposits	$	—	$	—	$	—		$	—	$	249.0	$	—	$	—	$	249.0
Corporate debt securities	—		—		—			—		1,047.2		—		—		1,047.2
Money market funds	2,562.9		—		—			2,562.9		837.7		—		—		837.7
Municipal debt securities	1,829.0		—		(0.5		)	1,828.5		4,740.9		0.8		—		4,741.7
Total	$	4,391.9	$	—	$	(0.5	)	$	4,391.4	$	6,874.8	$	0.8	$	—	$	6,875.6

Estimated fair values of available-for-sale securities are generally based on prices obtained from commercial pricing services. The following table summarizes the classification of the available-for-sale debt securities on our Consolidated Balance Sheets (in thousands):



	September 30, 2016		December 31, 2015
Cash and cash equivalents	$	4,391.4	$	6,875.6
Marketable securities	—		—
Total	$	4,391.4	$	6,875.6

The following table summarizes our portfolio of available-for-sale debt securities by contractual maturity (in thousands):



	September 30, 2016
	Amortized Cost		Estimated Fair Value
Less than one year	$	4,391.9	$	4,391.4
Greater than one year	—		—
Total	$	4,391.9	$	4,391.4

Deferred Costs	9 Months Ended
Deferred Costs	Sep. 30, 2016
Inventories [Abstract]
Deferred Costs	Deferred Costs Deferred costs, representing work in process for costs incurred on process development contracts that have not been completed, were $4.3 million and $2.9 million as of September 30, 2016 and December 31, 2015, respectively. The Company also has deferred revenue of approximately $4.9 million and $4.9 million of advance billings received as of September 30, 2016 and December 31, 2015, respectively, related to these contracts.

Loss Per Share

9 Months Ended

Sep. 30, 2016

Loss Per Share [Abstract]

Loss Per Share [Text Block]

Loss Per Share

For the three and nine months ended September 30, 2016 and 2015, the Company incurred net losses and therefore no common stock equivalents were utilized in the calculation of loss per share as they are anti-dilutive. At September 30, 2016 and 2015, the Company excluded the following potentially dilutive securities:



	September 30
	2016	2015
Stock Options	942,129	661,148
Warrants	362,650	351,645
Restricted Shares	61,456	11,358

Fair Value Measurements

9 Months Ended

Sep. 30, 2016

Fair Value Measurements [Abstract]

Fair Value Disclosures [Text Block]

Fair Value Measurements

The fair value of financial assets and liabilities that are being measured and reported are defined as the exchange price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants in the principal market at the measurement date (exit price). The Company is required to classify fair value measurements in one of the following categories:

Level 1 inputs are defined as quoted prices (unadjusted) in active markets for identical assets or liabilities that the reporting entity has the ability to access at the measurement date.

Level 2 inputs are defined as inputs other than quoted prices included within Level 1 that are observable for the assets or liabilities, either directly or indirectly.

Level 3 inputs are defined as unobservable inputs for the assets or liabilities. Financial assets and liabilities are classified based on the lowest level of input that is significant to the fair value measurement. The Company’s assessment of the significance of a particular input to the fair value measurement requires judgment, and may affect the valuation of the fair value of assets and liabilities and their placement within the fair value hierarchy levels.

The Company had no financial assets and liabilities that were accounted for at fair value on a recurring basis as of September 30, 2016, and December 31, 2015.

- Definition

The entire disclosure for the fair value of financial instruments (as defined), including financial assets and financial liabilities (collectively, as defined), and the measurements of those instruments as well as disclosures related to the fair value of non-financial assets and liabilities. Such disclosures about the financial instruments, assets, and liabilities would include: (1) the fair value of the required items together with their carrying amounts (as appropriate); (2) for items for which it is not practicable to estimate fair value, disclosure would include: (a) information pertinent to estimating fair value (including, carrying amount, effective interest rate, and maturity, and (b) the reasons why it is not practicable to estimate fair value; (3) significant concentrations of credit risk including: (a) information about the activity, region, or economic characteristics identifying a concentration, (b) the maximum amount of loss the entity is exposed to based on the gross fair value of the related item, (c) policy for requiring collateral or other security and information as to accessing such collateral or security, and (d) the nature and brief description of such collateral or security; (4) quantitative information about market risks and how such risks are managed; (5) for items measured on both a recurring and nonrecurring basis information regarding the inputs used to develop the fair value measurement; and (6) for items presented in the financial statement for which fair value measurement is elected: (a) information necessary to understand the reasons for the election, (b) discussion of the effect of fair value changes on earnings, (c) a description of [similar groups] items for which the election is made and the relation thereof to the balance sheet, the aggregate carrying value of items included in the balance sheet that are not eligible for the election; (7) all other required (as defined) and desired information.

+ References + Details

Goodwill and Other Intangible Assets

9 Months Ended

Sep. 30, 2016

Goodwill and Other Intangible Assets [Abstract]

Goodwill and Intangible Assets [Text Block]

Goodwill and Other Intangible Assets

The Company's goodwill was $7.0 million as of September 30, 2016 and December 31, 2015. All goodwill resides in the PCT reporting unit.

The Company's intangible assets and related accumulated amortization as of September 30, 2016 and December 31, 2015 consisted of the following (in thousands):



		September 30, 2016							December 31, 2015
	Useful Life	Gross		Accumulated Amortization			Net		Gross		Accumulated Amortization			Net
Customer list	10 years	$	1,000.0	$	(570.1	)	$	429.9	$	1,000.0	$	(495.1	)	$	504.9
Manufacturing technology	10 years	3,900.0		(2,223.4		)	1,676.6		3,900.0		(1,930.9		)	1,969.1
Tradename	10 years	800.0		(456.1		)	343.9		800.0		(396.1		)	403.9
Total Intangible Assets		$	5,700.0	$	(3,249.6	)	$	2,450.4	$	5,700.0	$	(2,822.1	)	$	2,877.9

Total intangible amortization expense was classified in the operating expense categories for the periods included below as follows (in thousands):



	Three Months Ended September 30,				Nine Months Ended September 30,
	2016		2015		2016		2015
Cost of revenue	$	78.5	$	79.2	$	235.8	$	229.7
Research and development	19.0		27.1		56.7		89.2
Selling, general and administrative	45.0		45.0		135.0		135.0
Total	$	142.5	$	151.3	$	427.5	$	453.9

Estimated intangible amortization expense for the succeeding five years is as follows (in thousands):



2016	$	142.5
2017	570.0
2018	570.0
2019	570.0
2020	570.0
Thereafter	27.9
Total	$	2,450.4

Accrued Liabilities

9 Months Ended

Sep. 30, 2016

Accrued Liabilities [Abstract]

Accounts Payable and Accrued Liabilities Disclosure [Text Block]

Accrued Liabilities

Accrued liabilities as of September 30, 2016 and December 31, 2015 were as follows (in thousands):



	September 30, 2016		December 31, 2015
Salaries, employee benefits and related taxes	$	4,093.0	$	2,771.2
Professional fees	376.7		480.7
Other	1,903.1		2,946.5
Total	$	6,372.8	$	6,198.4

Debt

9 Months Ended

Sep. 30, 2016

Debt [Abstract]

Debt Disclosure [Text Block]

Debt

Notes Payable

As of September 30, 2016 and December 31, 2015, the Company had notes payable of approximately $1.0 million and $1.8 million, respectively. The notes relate to certain insurance policies and equipment financings, require monthly payments, and mature within one to three years.

Long-Term Debt

On September 26, 2014, the Company entered into a loan and security agreement (the “Loan and Security Agreement”) with Oxford Finance LLC (together with its successors and assigns, the “Lender”) pursuant to which the Lender disbursed $15.0 million (the “Loan”). The debt offering/issuance costs have been recorded as debt issuance costs in other assets in the consolidated balance sheet, and will be amortized to interest expense throughout the life of the Loan using the effective interest rate method.

On March 11, 2016, upon execution of the Hitachi Transaction, the Company and the Lender entered into an amendment to the Loan and Security Agreement whereby (i) the Company paid $7.0 million to Lender, comprising principal, interest and early termination fees, (ii) the Company's subsidiaries PCT, PCT Allendale, LLC, and NeoStem Family Storage, LLC (collectively the "Removed Borrowers") were removed as borrowers under the Loan, (iii) Lender's security interests in any and all assets of the Removed Borrowers were released, (iv) the interest only period on the remaining outstanding Loan balance was extended until January 1, 2017, and (v) in the event the Company received gross proceeds from the sale or issuance of any equity securities or subordinated debt, or any partnership, licenses, collaboration, dividend, grant or asset sale through March 31, 2017, 20% of such proceeds will be paid to Lender, up to a $3.0 million maximum as additional partial repayment of Loan. On September 14, 2016, concurrent with the Company's September 2016 Registered Direct Offering and Concurrent Private Placement, the Company repaid $3.0 million of such proceeds to the Lender. The outstanding balance was approximately $5.7 million and $15.0 million at September 30, 2016 and December 31, 2015, respectively, of which $2.3 million is payable within twelve months as of September 30, 2016.

The Company is making interest-only payments on the outstanding amount of the Loan on a monthly basis at a rate of 8.50% per annum. Commencing on January 1, 2017, the Company will make 21 consecutive monthly payments of principal and interest. The Loan matures on September 1, 2018. At its option, the Company may prepay all amounts owed under the Loan and Security Agreement (including all accrued and unpaid interest), subject to a prepayment fee that is determined based on the date the loan is prepaid. The Company is also required to pay Lender a final payment fee equal to 8% of the Loan. The final payment fee will be amortized to interest expense throughout the life of the Loan using the effective interest rate method. The Company paid a facility fee in the amount of $100,000 in connection with the Loan.

Under the Loan and Security Agreement, the Lender holds a security interest ("Lenders' Security Interest") in all of the Company’s property, excluding the security interests in any and all assets of the Removed Borrowers, and excluding intellectual property and certain other assets and exemptions. The Lender also holds a security interest in the shares owned by the Company in the Company’s subsidiaries. The Loan and Security Agreement restricts the ability of the Company to: (a) convey, lease, sell, transfer or otherwise dispose of any part of Lenders' Security Interest and (b) incur any additional indebtedness. The Loan and Security Agreement provides for standard indemnification of Lender and contains representations, warranties and certain covenants of the Company. Upon the occurrence of an event of default by the Company under the Loan and Security Agreement, Lender will have customary acceleration, collection and foreclosure remedies. There are no financial covenants associated to the Loan and Security Agreement. As of September 30, 2016, the Company was in compliance with all covenants under the Loan and Security Agreement.

Estimated future principal payments, interest, and fees due under the Loan and Security Agreement are as follows:



Years Ending December 31,	(in millions)
2016	$	0.1
2017	3.5
2018	3.1
Total	$	6.7

During the three and nine months ended September 30, 2016, the Company recognized $0.2 million and $0.7 million of interest expense, respectively, related to the Loan and Security Agreement. During the three and nine months ended September 30, 2015, the Company recognized $0.3 million and $1.0 million of interest expense, respectively, related to the Loan and Security Agreement.

Redeemable Securities	9 Months Ended
Redeemable Securities	Sep. 30, 2016
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]
Redeemable Securities [Text Block]	Redeemable Securities Under the Hitachi Transaction (see Note 3), Hitachi may, at any time following the 10th anniversary of the Hitachi Transaction closing date on March 11, 2016, have the right on one occasion to require Caladrius or PCT to purchase all or some of the equity securities in PCT then held by Hitachi ("Hitachi Put Right") for an amount equal to the lower of (i) the fair market value of the Hitachi equity holdings and (ii) the original purchase price paid of $19.4 million on March 11, 2016 for its 19.9% ownership interest, plus interest at a rate of 2.0% per annum compounded annually; provided, however, that if Hitachi ownership interests increases subsequent to its initial ownership interest, and it offers to sell its equity holdings in excess of 21% of PCT’s outstanding equity securities, then the Company shall be required to purchase all such equity holdings of Hitachi but in no event shall the aggregate purchase price of such Hitachi equity holdings exceed $20.5 million plus interest at the rate of 2.0% per annum compounded annually. Since Hitachi has the right to deliver the equity interests in PCT it holds in exchange for cash from Caladrius or PCT, the initial $19.4 million value of the non-controlling interest is considered redeemable equity, requiring it to be treated as mezzanine equity. Redeemable non-controlling interest is required to be initially measured at the initial carrying amount. If the non-controlling interest is not currently redeemable and also not probable of becoming redeemable (e.g., it is not probable a contingency that triggers redemption will be met), the non-controlling interest should be classified in mezzanine equity.

Shareholders' Equity

9 Months Ended

Sep. 30, 2016

Shareholders’ Equity [Abstract]

Stockholders' Equity Note Disclosure [Text Block]

Shareholders' Equity

Reverse Stock Split

On July 28, 2016, the Company implemented the Reverse Stock Split, as authorized at the annual meeting of stockholders on June 22, 2016 and unanimously approved by the Company’s board of directors on July 22, 2016. The Reverse Stock Split became effective on July 27, 2016 at 5:00pm and the common stock of the Company began trading on The NASDAQ Capital Market on a post-split basis at the open of business on July 28, 2016. As of July 28, 2016, every ten shares of the Company’s issued and outstanding common stock were combined into one share of its common stock, except to the extent that the Reverse Stock Split resulted in any of the Company’s stockholders owning a fractional share, which was rounded up to the next highest whole share. In connection with the Reverse Stock Split, there was no change in the nominal par value per share of $0.001.

Equity Issuances

March 2016 Private Placement

On March 10, 2016, the Company entered into a securities purchase agreement with certain investors, pursuant to which the Company issued and sold in a private placement an aggregate of 141,844 shares of common stock and two-year warrants to purchase up to an aggregate of 141,844 shares of the Company's common stock, at an exercise price of $10.00 per share. The unit purchase price for a share of the Company's common stock and warrant to purchase one share of the Company's common stock was $7.05 per unit, with $1.0 million of gross proceeds received by the Company. On April 8, 2016, the Company filed a registration statement on Form S-3 to register the shares of common stock and the shares of common stock issuable upon exercise of the warrants acquired in the private placement, which registration statement became effective on June 7, 2016.

September 2016 Registered Direct Offering and Concurrent Private Placement

On September 14, 2016, the Company entered into a securities purchase agreement (the “RD Purchase Agreement”) with a single institutional investor (the “Purchaser”), pursuant to which the Company issued and sold to the Purchaser, in a registered direct offering, an aggregate of 847,458 shares of the Company’s common stock at a purchase price of $4.72 per share. The gross proceeds to the Company from the registered direct offering of the shares of common stock were $4.0 million.

In concurrent private placements, on September 14, 2016, the Company entered into Securities Purchase Agreements (each a “Private Placement Purchase Agreement” and, collectively, the “Private Placement Purchase Agreements”) with certain accredited investors (the “Investors”) with whom it had a substantive, pre-existing relationship, including certain existing stockholders, for the sale by the Company of an aggregate of 4,449,153 shares of Common Stock, at a purchase price of $4.72 per share. The investments will be placed in two tranches: (i) $12.6 million upon an initial closing (the “Initial Closing”), and (ii) $8.4 million, subject to certain conditions, including the enrollment of 70 subjects in the Company’s Phase 2 CLBS03 clinical trial, in a second closing (the “Second Closing”). As of September 30, 2016, $6.6 million of the Initial Closing tranche was received, and 1,398,305 shares of common stock had been issued. Based on management's expectations, the remaining $6.0 million of the Initial Closing tranche is expected to be received in the fourth quarter of 2016, and 1,271,186 shares of common stock will then be issued.

Aspire Purchase Agreements

In November 2015, the Company entered into a common stock purchase agreement (the "Purchase Agreement") with Aspire Capital Fund, LLC, an Illinois limited liability company (“Aspire Capital”), which provides that, subject to certain terms and conditions, Aspire Capital is committed to purchase up to an aggregate of $30 million of shares (limited to a maximum of approximately 1.1 million shares, unless stockholder approval is obtained or certain minimum sale price levels are reached) of the Company's common stock over a 24-month term. As consideration for entering into the Purchase Agreement, the Company issued 84,270 shares of its common stock to Aspire Capital. During the nine months ended September 30, 2016, the Company issued 5,000 shares of common stock under the Purchase Agreement for gross proceeds of $0.03 million. Overall, as of September 30, 2016, the Company has issued 109,270 shares under the Purchase Agreement for gross proceeds of $0.3 million.

Under the Purchase Agreement, at the Company’s discretion, it may present Aspire Capital with purchase notices from time to time to purchase the Company’s common stock, provided certain price, trading volume and conditions, including NASDAQ's trading requirements, are met. The purchase price for the shares of common stock is based upon one of two formulas set forth in the Purchase Agreement depending on the type of purchase notice the Company submits to Aspire Capital, and is based on market prices of the Company’s common stock (in the case of regular purchases) or a discount of 5% applied to volume weighted average prices (in the case of VWAP purchases), in each case as determined by parameters defined in the Purchase Agreements. We have filed a registration statement with the SEC and a related prospectus supplement that covers the offering of shares of our common stock subject to the Purchase Agreement, and therefore can initiate sales to Aspire Capital at any time, subject to the limitation discussed above.

We are party to one other existing agreement with Aspire Capital (the "May 2015 Purchase Agreement"). The registration statement we previously filed with the SEC to cover offerings of shares of our common stock subject to the May 2015 Purchase Agreement has expired, and we have not, and currently have no intention to include such shares in a registration statement filed with the SEC. Unless and until we include such shares in a registration statement filed with the SEC, we are unable to initiate sales to Aspire under the May 2015 Purchase Agreement. Under the May 2015 Purchase Agreement, Aspire Capital is committed to purchase up to an aggregate of $30 million of shares. As consideration for entering into the May 2015 Purchase Agreement, the Company issued 36,484 shares of its common stock to Aspire Capital. The Company has not issued any additional shares under the May 2015 Purchase Agreement.

Stock Options and Warrants

The following table summarizes the activity for stock options and warrants for the nine months ended September 30, 2016, as adjusted for the Reverse Stock Split:



	Stock Options							Warrants
	Shares		Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (Years)	Aggregate Intrinsic Value (In Thousands)		Shares		Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (Years)	Aggregate Intrinsic Value (In Thousands)
Outstanding at December 31, 2015	666,348		$	64.60	6.88	$	0.1	321,404		$	137.20	1.26	$	—

Changes during the period:
Granted	448,365		5.30					141,845		10.00
Exercised	—		—					—		—
Forfeited	(61,983	)	34.20					—		—
Expired	(110,601	)	45.90					(100,850	)	145.10
Outstanding at September 30, 2016	942,129		$	40.90	7.95	$	0.2	362,399		$	85.40	1.08	$	—
Vested at September 30, 2016 or expected to vest in the future	938,964		$	41.10	7.93	$	0.2	362,399		$	85.40	1.08	$	—
Vested at September 30, 2016	761,371		$	47.30	7.65	$	—	362,650		$	85.40	1.08	$	—

Restricted Stock

During the nine months ended September 30, 2016 and 2015, the Company issued restricted stock for services as follows (in thousands, except share data):



	Nine Months Ended September 30,
	2016		2015
Number of Restricted Stock Issued	107,719		81,184
Value of Restricted Stock Issued	$	651.7	$	2,367.5

The weighted average estimated fair value of restricted stock issued for services in the nine months ended September 30, 2016 and 2015 was $6.05 and $29.16 per share, respectively. The fair value of the restricted stock was determined using the Company’s closing stock price on the date of issuance, as adjusted for the Reverse Stock Split.

- Definition

The entire disclosure for shareholders' equity comprised of portions attributable to the parent entity and noncontrolling interest, including other comprehensive income. Includes, but is not limited to, balances of common stock, preferred stock, additional paid-in capital, other capital and retained earnings, accumulated balance for each classification of other comprehensive income and amount of comprehensive income.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08.(d),(e))
-URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section 50
-Paragraph 4
-URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21484-112644

Reference 3: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
-Topic 310
-SubTopic 10
-Section S99
-Paragraph 2
-Subparagraph (SAB TOPIC 4.E)
-URI http://asc.fasb.org/extlink&oid=27010918&loc=d3e74512-122707

Reference 4: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section 50
-Paragraph 5
-URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21488-112644

Reference 5: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02.29-31)
-URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682

Reference 6: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section S99
-Paragraph 4
-Subparagraph (SAB TOPIC 4.C)
-URI http://asc.fasb.org/extlink&oid=27012166&loc=d3e187143-122770

Reference 7: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section 50
-Paragraph 6
-URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21506-112644

Reference 8: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.3-04)
-URI http://asc.fasb.org/extlink&oid=27012166&loc=d3e187085-122770

Reference 9: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 30
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=6405834&loc=d3e23285-112656

Reference 10: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section 50
-Paragraph 3
-URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21475-112644

Reference 11: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Glossary Preferred Stock
-URI http://asc.fasb.org/extlink&oid=6521494

Reference 12: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
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-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21463-112644

Reference 13: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section 50
-Paragraph 11
-URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21564-112644

Reference 14: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Staff Accounting Bulletin (SAB)
-Number Topic 4
-Section E

Reference 15: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Staff Accounting Bulletin (SAB)
-Number Topic 4
-Section C

+ Details

Share-Based Compensation

9 Months Ended

Sep. 30, 2016

Share-based Compensation [Abstract]

Disclosure of Compensation Related Costs, Share-based Payments [Text Block]

Share-Based Compensation

Share-based Compensation

We utilize share-based compensation in the form of stock options, warrants and restricted stock. The following table summarizes the components of share-based compensation expense for the three and nine months ended September 30, 2016 and 2015 (in thousands):



	Three Months Ended September 30,				Nine Months Ended September 30,
	2016		2015		2016		2015
Cost of goods sold	$	11.7	$	14.4	$	306.3	$	509.5
Research and development	6.0		115.9		298.3		1,642.8
Selling, general and administrative	317.8		306.2		1,671.0		6,416.2
Total share-based compensation expense	$	335.5	$	436.5	$	2,275.6	$	8,568.5

Total compensation cost related to nonvested awards not yet recognized and the weighted-average periods over which the awards are expected to be recognized at September 30, 2016 were as follows (in thousands):



	Stock Options		Restricted Stock
Unrecognized compensation cost	$	2,178.3	$	454.0
Expected weighted-average period in years of compensation cost to be recognized	1.29		1.87

Total fair value of shares vested and the weighted average estimated fair values of shares granted for the nine months ended September 30, 2016 and 2015 were as follows, as adjusted for the Reverse Stock Split (in thousands):



	Stock Options
	Nine Months Ended September 30,
	2016		2015
Total fair value of shares vested	$	2,189.4	$	5,303.9
Weighted average estimated fair value of shares granted	$	3.25	$	21.03

Valuation Assumptions

The fair value of stock options and warrants at the date of grant was estimated using the Black-Scholes option pricing model. The expected volatility is based upon historical volatility of the Company’s stock. The expected term for the options is based upon observation of actual time elapsed between date of grant and exercise of options for all employees. The expected term for the warrants is based upon the contractual term of the warrants.

Income Taxes	9 Months Ended
Income Taxes	Sep. 30, 2016
Income Taxes [Abstract]
Income Tax Disclosure [Text Block]	Income Taxes As of December 31, 2015, the Company had approximately $221.5 million of Federal net operating loss carryforwards ("NOLs") available to offset future taxable income expiring from 2025 through 2035. In accordance with Section 382 of the Internal Revenue code, the usage of the Company’s NOLs could be limited in the event of a change in ownership. The ultimate realization of deferred tax assets is dependent upon the generation of future taxable income during the period when those temporary differences become deductible. If a change of ownership did occur there would be an annual limitation on the usage of the Company’s losses which are available through 2035. In assessing the ability to realize deferred tax assets, including the NOLs, the Company assesses the available positive and negative evidence to estimate if sufficient future taxable income will be generated to utilize its existing deferred tax assets. Based on its assessment, the Company has provided a full valuation allowance against its net deferred tax assets as the Company's ability to generate taxable income remains uncertain at this time. Deferred tax liabilities were $1.1 million and $0.9 million as of September 30, 2016 and December 31, 2015, respectively, and relate to the taxable temporary differences on the goodwill recognized in the PCT acquisition in 2011. The taxable temporary differences, which are tax deductible and will be amortized over 15 years, will continue to increase the deferred tax liability balance over the amortization period, with an associated charge to the deferred tax provision in each period. The deferred tax liability will only reverse when the indefinite-lived asset is sold, impaired, or reclassified from an indefinite-lived asset to a finite-lived asset. As of September 30, 2016, management does not believe the Company has any material uncertain tax positions that would require it to measure and reflect the potential lack of sustainability of a position on audit in its financial statements. The Company will continue to evaluate its uncertain tax positions in future periods to determine if measurement and recognition in its financial statements is necessary. The Company does not believe there will be any material changes in its unrecognized tax positions over the next year. The Company's federal tax returns are currently being audited for the years 2012 and 2013. For years prior to 2011 the federal statute of limitations is closed for assessing tax. The Company’s state tax returns remain open to examination for a period of three to four years from date of filing. The Company ceased doing business in China in 2012. After 2012, the Company had no foreign tax filing obligations. The foreign returns filed for 2012 and prior are subject to examination for five years.

Commitments and Contingencies

9 Months Ended

Sep. 30, 2016

Commitments and Contingencies [Abstract]

Commitments and Contingencies [Text Block]

Commitments and Contingencies

Lease Commitments

We entered into an assignment agreement with an unaffiliated third party, effective February 19, 2015, for general office space located in Basking Ridge, NJ. This property is used as the Company's corporate headquarters. The space is approximately 18,000 rentable square feet. The base monthly rent is currently $31,875 and the lease term ends July 31, 2020. In addition, there are two five-year renewal options. In connection with the assumption of the lease, the third party (a) conveyed its rights in various scheduled furniture and equipment and (b) paid the Company approximately $580,000. The amount paid to the Company included a security deposit of approximately $115,000. The Company also leases facilities in New York, NY, Irvine, CA, and Mountain View, CA, of which certain have escalation clauses and renewal options, and also leases equipment under certain noncancelable operating leases that expire from time to time through 2021.

A summary of future minimum rental payments required under operating leases that have initial or remaining terms in excess of one year as of September 30, 2016 are as follows (in thousands):



Years ended	Operating Leases
2016	$	520.3
2017	1,876.5
2018	1,046.7
2019	994.9
2020 and thereafter	960.2
Total minimum lease payments	$	5,398.6

Expense incurred under operating leases was approximately $1.5 million and $1.2 million for the nine months ended September 30, 2016 and 2015, respectively.

Contingencies

We have entered into a strategic collaboration with Sanford Research with the goal of developing a therapy for the treatment of T1D. The initial focus of the collaboration will be the execution of a prospective, randomized, placebo-controlled, double-blind clinical trial (The Sanford Project: T-Rex Study) to evaluate the safety and efficacy of the Company’s T regulatory cell product candidate, CLBS03, in adolescents with recent onset T1D. The Phase 2 study has an open and active IND in place and subject enrollment commenced in the first quarter of 2016. We were initially responsible for the supply of all study drug to the first 19 enrolled patients while Sanford assumed all patient and clinical site costs for subjects enrolled in their two centers as well as the expense associated with general clinical monitoring services. For the remaining 92 patients in the study, we will continue to be responsible for the supply of all study drug and the costs of study enrollment for sites outside of the Sanford centers.

Under license agreements with third parties the Company is typically required to pay maintenance fees, make milestone payments and/or pay other fees and expenses and pay royalties upon commercialization of products. The Company also sponsors research at various academic institutions, which research agreements generally provide us with an option to license new technology discovered during the course of the sponsored research.

Under the Hitachi Transaction, Hitachi may require the Company to purchase all of its ownership in PCT if a Change of Control has occurred (as defined in the Amended and Restated Operating Agreement of PCT), and if such Change of Control can reasonably be expected to have a material adverse effect on PCT’s ability to conduct its business in the ordinary course consistent with its past practice and its then current annual budget, at a price to be agreed upon by mutual agreement, provided, however, if mutual agreement is not obtained, the price will be determined by independent valuation firms.

From time to time, the Company is subject to legal proceedings and claims, either asserted or unasserted, that arise in the ordinary course of business. While the outcome of pending claims cannot be predicted with certainty, the Company does not believe that the outcome of any pending claims will have a material adverse effect on the Company's financial condition or operating results.

Subsequent Events	9 Months Ended
Subsequent Events	Sep. 30, 2016
Subsequent Events [Abstract]
Subsequent Events	Subsequent Events

Summary of Significant Accounting Policies (Policies)

9 Months Ended

Sep. 30, 2016

Summary of Significant Accounting Policies [Abstract]

Schedule of Cash and Cash Equivalents [Table Text Block]

Concentration of Risks

Share-based Compensation, Option and Incentive Plans Policy [Policy Text Block]

Share-Based Compensation

Goodwill and Intangible Assets, Policy [Policy Text Block]

Goodwill

Definite-Lived Intangible Assets

Revenue Recognition, Policy [Policy Text Block]

Revenue Recognition

Clinical Services: The Company recognizes revenue for its (i) process development and (ii) clinical manufacturing services based on the terms of individual contracts.

We recognize revenues when all of the following conditions are met:


•	persuasive evidence of an arrangement exists;


•	delivery has occurred or the services have been rendered;


•	the fee is fixed or determinable; and


•	collection is probable.

New Accounting Pronouncements, Policy [Policy Text Block]

Recently Issued Accounting Pronouncement

- Definition

Disclosure of accounting policy for cash and cash equivalents, including the policy for determining which items are treated as cash equivalents. Other information that may be disclosed includes (1) the nature of any restrictions on the entity's use of its cash and cash equivalents, (2) whether the entity's cash and cash equivalents are insured or expose the entity to credit risk, (3) the classification of any negative balance accounts (overdrafts), and (4) the carrying basis of cash equivalents (for example, at cost) and whether the carrying amount of cash equivalents approximates fair value.

+ References + Details

- Definition

Disclosure of accounting policy for revenue recognition. If the entity has different policies for different types of revenue transactions, the policy for each material type of transaction is generally disclosed. If a sales transaction has multiple element arrangements (for example, delivery of multiple products, services or the rights to use assets) the disclosure may indicate the accounting policy for each unit of accounting as well as how units of accounting are determined and valued. The disclosure may encompass important judgment as to appropriateness of principles related to recognition of revenue. The disclosure also may indicate the entity's treatment of any unearned or deferred revenue that arises from the transaction.

+ References + Details

The Business (Tables)

9 Months Ended

Sep. 30, 2016

The Business [Abstract]

Summary of Principles of Consolidation



Entity	Percentage of Ownership	Location
Caladrius Biosciences, Inc.	100%	United States of America
Amorcyte, LLC	100%	United States of America
PCT, LLC, a Caladrius Company (1)	80.1%	United States of America
NeoStem Family Storage, LLC (1)	80.1%	United States of America
Athelos Corporation (2)	98.2%	United States of America
PCT Allendale, LLC (1)	80.1%	United States of America
NeoStem Oncology, LLC	100%	United States of America

_________________________________________________________________

(1) As of September 30, 2016, Hitachi's ownership interest was 19.9% (see Note 3).

(2) As of September 30, 2016, Becton Dickinson's ownership interest was 1.8%.

Available-for-Sale-Securities (Tables)

9 Months Ended

Sep. 30, 2016

Available-for-sale Securities [Abstract]

Schedule of Available-for-sale Securities Reconciliation [Table Text Block]

The following table is a summary of available-for-sale securities recorded in cash and cash equivalents or marketable securities in our Consolidated Balance Sheets (in thousands):



	September 30, 2016									December 31, 2015
	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Estimated Fair Value		Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses		Estimated Fair Value
Certificate of deposits	$	—	$	—	$	—		$	—	$	249.0	$	—	$	—	$	249.0
Corporate debt securities	—		—		—			—		1,047.2		—		—		1,047.2
Money market funds	2,562.9		—		—			2,562.9		837.7		—		—		837.7
Municipal debt securities	1,829.0		—		(0.5		)	1,828.5		4,740.9		0.8		—		4,741.7
Total	$	4,391.9	$	—	$	(0.5	)	$	4,391.4	$	6,874.8	$	0.8	$	—	$	6,875.6

Marketable Securities [Table Text Block]



	September 30, 2016		December 31, 2015
Cash and cash equivalents	$	4,391.4	$	6,875.6
Marketable securities	—		—
Total	$	4,391.4	$	6,875.6

Investments Classified by Contractual Maturity Date [Table Text Block]

The following table summarizes our portfolio of available-for-sale debt securities by contractual maturity (in thousands):



	September 30, 2016
	Amortized Cost		Estimated Fair Value
Less than one year	$	4,391.9	$	4,391.4
Greater than one year	—		—
Total	$	4,391.9	$	4,391.4

Loss Per Share (Tables)

9 Months Ended

Sep. 30, 2016

Loss Per Share [Abstract]

ScheduleOfDilutiveSecuritiesExcludedFromComputationOfEarningsPerShare [Table Text Block]

At September 30, 2016 and 2015, the Company excluded the following potentially dilutive securities:



	September 30
	2016	2015
Stock Options	942,129	661,148
Warrants	362,650	351,645
Restricted Shares	61,456	11,358

Goodwill and Other Intangible Assets (Tables)

9 Months Ended

Sep. 30, 2016

Goodwill and Other Intangible Assets [Abstract]

Schedule of Finite-Lived Intangible Assets by Major Class [Table Text Block]

The Company's intangible assets and related accumulated amortization as of September 30, 2016 and December 31, 2015 consisted of the following (in thousands):



		September 30, 2016							December 31, 2015
	Useful Life	Gross		Accumulated Amortization			Net		Gross		Accumulated Amortization			Net
Customer list	10 years	$	1,000.0	$	(570.1	)	$	429.9	$	1,000.0	$	(495.1	)	$	504.9
Manufacturing technology	10 years	3,900.0		(2,223.4		)	1,676.6		3,900.0		(1,930.9		)	1,969.1
Tradename	10 years	800.0		(456.1		)	343.9		800.0		(396.1		)	403.9
Total Intangible Assets		$	5,700.0	$	(3,249.6	)	$	2,450.4	$	5,700.0	$	(2,822.1	)	$	2,877.9

Schedule of Amortization Expense [Table Text Block]

Total intangible amortization expense was classified in the operating expense categories for the periods included below as follows (in thousands):



	Three Months Ended September 30,				Nine Months Ended September 30,
	2016		2015		2016		2015
Cost of revenue	$	78.5	$	79.2	$	235.8	$	229.7
Research and development	19.0		27.1		56.7		89.2
Selling, general and administrative	45.0		45.0		135.0		135.0
Total	$	142.5	$	151.3	$	427.5	$	453.9

Schedule of Finite-Lived Intangible Assets, Future Amortization Expense [Table Text Block]

Estimated intangible amortization expense for the succeeding five years is as follows (in thousands):



2016	$	142.5
2017	570.0
2018	570.0
2019	570.0
2020	570.0
Thereafter	27.9
Total	$	2,450.4

Accrued Liabilities (Tables)

9 Months Ended

Sep. 30, 2016

Accrued Liabilities [Abstract]

Schedule of Accrued Liabilities [Table Text Block]

Accrued liabilities as of September 30, 2016 and December 31, 2015 were as follows (in thousands):



	September 30, 2016		December 31, 2015
Salaries, employee benefits and related taxes	$	4,093.0	$	2,771.2
Professional fees	376.7		480.7
Other	1,903.1		2,946.5
Total	$	6,372.8	$	6,198.4

Debt Long term debt (Tables)

9 Months Ended

Sep. 30, 2016

Long-term Debt, Unclassified [Abstract]

Schedule of Maturities of Long-term Debt [Table Text Block]

Estimated future principal payments, interest, and fees due under the Loan and Security Agreement are as follows:



Years Ending December 31,	(in millions)
2016	$	0.1
2017	3.5
2018	3.1
Total	$	6.7

Shareholders' Equity (Tables)

9 Months Ended

Sep. 30, 2016

Shareholders’ Equity [Abstract]

Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]

The following table summarizes the activity for stock options and warrants for the nine months ended September 30, 2016, as adjusted for the Reverse Stock Split:



	Stock Options							Warrants
	Shares		Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (Years)	Aggregate Intrinsic Value (In Thousands)		Shares		Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (Years)	Aggregate Intrinsic Value (In Thousands)
Outstanding at December 31, 2015	666,348		$	64.60	6.88	$	0.1	321,404		$	137.20	1.26	$	—

Changes during the period:
Granted	448,365		5.30					141,845		10.00
Exercised	—		—					—		—
Forfeited	(61,983	)	34.20					—		—
Expired	(110,601	)	45.90					(100,850	)	145.10
Outstanding at September 30, 2016	942,129		$	40.90	7.95	$	0.2	362,399		$	85.40	1.08	$	—
Vested at September 30, 2016 or expected to vest in the future	938,964		$	41.10	7.93	$	0.2	362,399		$	85.40	1.08	$	—
Vested at September 30, 2016	761,371		$	47.30	7.65	$	—	362,650		$	85.40	1.08	$	—

Restricted Stock [Table Text Block]

During the nine months ended September 30, 2016 and 2015, the Company issued restricted stock for services as follows (in thousands, except share data):



	Nine Months Ended September 30,
	2016		2015
Number of Restricted Stock Issued	107,719		81,184
Value of Restricted Stock Issued	$	651.7	$	2,367.5

Share-Based Compensation (Tables)

9 Months Ended

Sep. 30, 2016

Share-based Compensation [Abstract]

Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]

The following table summarizes the components of share-based compensation expense for the three and nine months ended September 30, 2016 and 2015 (in thousands):



	Three Months Ended September 30,				Nine Months Ended September 30,
	2016		2015		2016		2015
Cost of goods sold	$	11.7	$	14.4	$	306.3	$	509.5
Research and development	6.0		115.9		298.3		1,642.8
Selling, general and administrative	317.8		306.2		1,671.0		6,416.2
Total share-based compensation expense	$	335.5	$	436.5	$	2,275.6	$	8,568.5

Disclosure of Share-based Compensation Arrangements by Share-based Payment Award [Table Text Block]



	Stock Options		Restricted Stock
Unrecognized compensation cost	$	2,178.3	$	454.0
Expected weighted-average period in years of compensation cost to be recognized	1.29		1.87

Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value [Table Text Block]



	Stock Options
	Nine Months Ended September 30,
	2016		2015
Total fair value of shares vested	$	2,189.4	$	5,303.9
Weighted average estimated fair value of shares granted	$	3.25	$	21.03

Commitments and Contingencies (Tables)

9 Months Ended

Sep. 30, 2016

Commitments and Contingencies [Abstract]

Schedule of Future Minimum Rental Payments for Operating Leases [Table Text Block]

A summary of future minimum rental payments required under operating leases that have initial or remaining terms in excess of one year as of September 30, 2016 are as follows (in thousands):



Years ended	Operating Leases
2016	$	520.3
2017	1,876.5
2018	1,046.7
2019	994.9
2020 and thereafter	960.2
Total minimum lease payments	$	5,398.6

The Business Cell Therapy Development and Manufacturing (Details) - PCT Allendale, LLC [Member]	12 Months Ended
	Dec. 31, 2015 client product filing
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Number Of Clients \| client	100
Number Of Products Produced \| product	20,000
Number Of Years Since Foundation	17 years
United States And European Union [Member]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Number Of Supported Regulatory Filings \| filing	50

The Business CLBS03 (Details)	12 Months Ended
The Business CLBS03 (Details)	Dec. 31, 2015 patient cohort
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Interim Efficacy Analysis, Percentage Threshold	50.00%
Interim Efficacy Analysis, Follow-up Milestone Period	6 years
The Sanford Project: T-Rex Study [Member]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Number of Cohorts \| cohort	2
Number Of Patients, Cohort One	19
Number Of Patients, Cohort Two	92

The Business Financial Information & Liquidity (Details) $ / shares in Units, $ in Thousands				1 Months Ended			9 Months Ended	12 Months Ended
	Sep. 14, 2016 USD ($) clinical_trial_subject $ / shares shares	Jul. 28, 2016 $ / shares	Mar. 11, 2016 USD ($)	Sep. 30, 2016 USD ($) $ / shares	Jun. 30, 2016 USD ($)	Mar. 31, 2016 USD ($)	Sep. 30, 2016 USD ($) $ / shares shares	Dec. 31, 2016 USD ($) shares	Mar. 10, 2016 $ / shares	Dec. 31, 2015 $ / shares
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Share Price \| $ / shares									$ 7.05
Reverse Stock Split, Conversion Ratio		0.1
Common Stock, Par Value \| $ / shares		$ 0.001		$ 0.001			$ 0.001			$ 0.001
Shares Issued, Price Per Share \| $ / shares	$ 4.72
Hitachi Chemical Co., LTD [Member]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Proceeds From Licensing Agreements			$ 25,000		$ 1,250	$ 22,500
Unrecorded Unconditional Purchase Obligation, Maximum Quantity			15,000
PCT Allendale, LLC [Member] \| Hitachi Chemical Co., LTD [Member]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Proceeds From Licensing Agreements			$ 10,000
Oxford Finance LLC [Member]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Repayments of Debt			$ 7,000	$ 3,000
RD Purchase Agreement [Member]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Stock Issued During Period, Shares, New Issues \| shares	847,458
Proceeds from Issuance of Common Stock	$ 4,000
Private Purchase Agreement [Member]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Stock Issued During Period, Shares, New Issues \| shares							1,398,305
Proceeds from Issuance of Common Stock							$ 6,600
Purchase Commitment, Maximum Amount Committed, Shares \| shares	4,449,153
Proceeds from Issuance of Common Stock, Initial Closing	$ 12,600
Proceeds from Issuance of Common Stock, Second Closing	$ 8,400
Number of Subjects, Phase 2 CLBS03 Clinical Trial, Second Closing \| clinical_trial_subject	70
Private Purchase Agreement [Member] \| Subsequent Event [Member]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Stock Issued During Period, Shares, New Issues \| shares								1,271,186
Proceeds from Issuance of Common Stock								$ 6,000

The Business Principal of consolidation (Details)	Sep. 30, 2016	Jun. 30, 2016	Mar. 11, 2016
Schedule of Subisidiary [Line Items]
Subsidiary, Ownership Interest by Parent			80.10%
NeoStem, Inc. [Member]
Schedule of Subisidiary [Line Items]
Subsidiary, Ownership Interest by Parent	100.00%
Amorcyte, LLC [Member] \| UNITED STATES
Schedule of Subisidiary [Line Items]
Subsidiary, Ownership Interest by Parent	100.00%
PCT Allendale, LLC [Member] \| UNITED STATES
Schedule of Subisidiary [Line Items]
Subsidiary, Ownership Interest by Parent	80.10%
Athelos Corporation [Member] \| UNITED STATES
Schedule of Subisidiary [Line Items]
Subsidiary, Ownership Interest by Parent	98.20%
NeoStem Oncology [Member] \| UNITED STATES
Schedule of Subisidiary [Line Items]
Subsidiary, Ownership Interest by Parent	100.00%
Hitachi Chemical Co., LTD [Member]
Schedule of Subisidiary [Line Items]
Noncontrolling Interest, Ownership Percentage by Noncontrolling Owners		19.90%
Becton Dickson [Member]
Schedule of Subisidiary [Line Items]
Noncontrolling Interest, Ownership Percentage by Noncontrolling Owners		1.80%

Summary of Significant Accounting Policies (Details) - USD ($)		3 Months Ended			6 Months Ended		9 Months Ended	12 Months Ended
	Jun. 30, 2016	Jun. 30, 2016	Mar. 31, 2016	Jun. 30, 2015	Jun. 30, 2016	Jun. 30, 2015	Sep. 30, 2016	Dec. 31, 2015	Mar. 11, 2016
Concentration Risk [Line Items]
Goodwill, Impairment Loss								$ 18,200,000
Clinical Services Reimbursement		$ 1,600,000		$ 900,000	$ 5,000,000	$ 2,300,000
Revene Recognition Period for Cryoperservation Process								24 hours
Unearned revenues							$ 5,869,586	$ 5,345,225
Customer Concentration Risk [Member] \| Sales Revenue, Net [Member]
Concentration Risk [Line Items]
Concentration Risk, Percentage			43.00%
Customer Concentration Risk [Member] \| Accounts Receivable [Member]
Concentration Risk [Line Items]
Concentration Risk, Percentage					37.00%
Customer One [Member] \| Customer Concentration Risk [Member] \| Sales Revenue, Net [Member]
Concentration Risk [Line Items]
Concentration Risk, Percentage					18.00%
Customer One [Member] \| Customer Concentration Risk [Member] \| Accounts Receivable [Member]
Concentration Risk [Line Items]
Concentration Risk, Percentage					15.00%
PCT Allendale, LLC [Member]
Concentration Risk [Line Items]
Contract Receivable									$ 5,600,000
Proceeds from License Fees Received	$ 4,400,000
Licenses Revenue		110,000			$ 200,000
Unearned revenues	400,000	400,000			400,000
Deferred Revenue, Noncurrent	$ 4,300,000	$ 4,300,000			$ 4,300,000
PCT Allendale, LLC [Member]
Concentration Risk [Line Items]
Length of Extension Contract for Royalty Payments from Revenue Generated in Asia							2 years
Minimum [Member] \| PCT Allendale, LLC [Member]
Concentration Risk [Line Items]
Length of Contract for Royalty Payments from Revenue Generated in Asia							10 years

Collaboration and License Agreement (Details) - USD ($) $ in Millions		9 Months Ended
	Jun. 30, 2016	Sep. 30, 2016	Mar. 31, 2016	Mar. 11, 2016
Business Acquisition [Line Items]
Equity Method Investment, Ownership Percentage				19.90%
Subsidiary, Ownership Interest by Parent				80.10%
Hitachi Chemical Co., LTD [Member]
Business Acquisition [Line Items]
Equity Method Investment, Ownership Percentage				21.00%
Recorded Unconditional Purchase Obligation			$ 20.5	$ 19.4
Unrecorded Unconditional Purchase Obligation, Maximum Quantity				15.0
PCT Allendale, LLC [Member]
Business Acquisition [Line Items]
Contract Receivable				$ 5.6
Proceeds from License Fees Received	$ 4.4
PCT Allendale, LLC [Member]
Business Acquisition [Line Items]
Purchase Obligation				$ 4.4
Minimum [Member] \| PCT Allendale, LLC [Member]
Business Acquisition [Line Items]
Length of Contract for Royalty Payments from Revenue Generated in Asia		10 years

Available-for-Sale-Securities Schedule of Available-for-sale Securites Reconciliation (Details) - USD ($)	Sep. 30, 2016	Dec. 31, 2015
Schedule of Available-for-sale Securities [Line Items]
Available-for-sale Securities, Amortized Cost Basis	$ 4,391,900	$ 6,874,800
Deferred Tax Liabilities, Unrealized Gains on Trading Securities	0	800
Available-for-sale Securities, Continuous Unrealized Loss Position, Fair Value	(500)	0
Certificates of Deposit, at Carrying Value	4,391,400	6,875,600
Certificates of Deposit [Member]
Schedule of Available-for-sale Securities [Line Items]
Available-for-sale Securities, Amortized Cost Basis	0	249,000
Deferred Tax Liabilities, Unrealized Gains on Trading Securities	0	0
Available-for-sale Securities, Continuous Unrealized Loss Position, Fair Value	0	0
Certificates of Deposit, at Carrying Value	0	249,000
Corporate Debt Securities [Member]
Schedule of Available-for-sale Securities [Line Items]
Available-for-sale Securities, Amortized Cost Basis	0	1,047,200
Deferred Tax Liabilities, Unrealized Gains on Trading Securities	0	0
Available-for-sale Securities, Continuous Unrealized Loss Position, Fair Value	0	0
Certificates of Deposit, at Carrying Value	0	1,047,200
Money Market Funds [Member]
Schedule of Available-for-sale Securities [Line Items]
Available-for-sale Securities, Amortized Cost Basis	2,562,900	837,700
Deferred Tax Liabilities, Unrealized Gains on Trading Securities	0	0
Available-for-sale Securities, Continuous Unrealized Loss Position, Fair Value	0	0
Certificates of Deposit, at Carrying Value	2,562,900	837,700
Municipal Bonds [Member]
Schedule of Available-for-sale Securities [Line Items]
Available-for-sale Securities, Amortized Cost Basis	1,829,000	4,740,900
Deferred Tax Liabilities, Unrealized Gains on Trading Securities	0	800
Available-for-sale Securities, Continuous Unrealized Loss Position, Fair Value	(500)	0
Certificates of Deposit, at Carrying Value	$ 1,828,500	$ 4,741,700

Available-for-Sale-Securities Classification of the available-for-sale securities (Details) - USD ($)	Sep. 30, 2016	Dec. 31, 2015
Available-for-sale Securities [Abstract]
Cash	$ 4,391,400	$ 6,875,600
Marketable securities	0	0
Total	$ 4,391,400	$ 6,875,600

Available-for-Sale-Securities Available-for-sale Securities by Contractual Maturity (Details)	Sep. 30, 2016 USD ($)
Available-for-sale Securities [Abstract]
Amortized Cost	$ 4,391,900
Available-for-sale Securities, Debt Maturities, Remainder of Fiscal Year, Amortized Cost Basis	4,391,400
Available-for-sale Securities, Debt Maturities, Year Two Through Five, Amortized Cost Basis	0
Available-for-sale Securities, Noncurrent	0
Estimated Fair Value	$ 4,391,400

- Definition

Investments in debt and equity securities which are categorized neither as held-to-maturity nor trading and which are intended to be sold or mature more than one year from the balance sheet date or operating cycle, if longer. Such securities are reported at fair value; unrealized gains (losses) related to Available-for-sale Securities are excluded from earnings and reported in a separate component of shareholders' equity (other comprehensive income), unless the Available-for-sale security is designated as a hedge or is determined to have had an other than temporary decline in fair value below its amortized cost basis. All or a portion of the unrealized holding gain (loss) of an Available-for-sale security that is designated as being hedged in a fair value hedge is recognized in earnings during the period of the hedge, as are other than temporary declines in fair value below the cost basis for investments in equity securities and debt securities that an entity intends to sell or it is more likely than not that it will be required to sell before the recovery of its amortized cost basis. Other than temporary declines in fair value below the cost basis for debt securities categorized as Available-for-sale that an entity does not intend to sell and for which it is not more likely than not that the entity will be required to sell before the recovery of its amortized cost basis are bifurcated into credit losses and losses related to all other factors. Other than temporary declines in fair value below cost basis related to credit losses are recognized in earnings, and losses related to all other factors are recognized in other comprehensive income.

+ References + Details

Deferred Costs (Details) - USD ($)	Sep. 30, 2016	Jun. 30, 2016	Dec. 31, 2015
Schedule of Inventory [Line Items]
Deferred costs	$ 4,315,977		$ 2,911,743
Multiple Stage Contracts [Member]
Schedule of Inventory [Line Items]
Deferred Revenue		$ 4,900,000	$ 4,900,000

Loss Per Share (Details) - shares	9 Months Ended
Loss Per Share (Details) - shares	Sep. 30, 2016	Sep. 30, 2015
Warrants
Class of Stock [Line Items]
Dilutive Securities Excluded From Computation Of Earnings Per Share, Shares	362,650	351,645
Stock Options [Member]
Class of Stock [Line Items]
Dilutive Securities Excluded From Computation Of Earnings Per Share, Shares	942,129	661,148
Restricted Stock [Member]
Class of Stock [Line Items]
Dilutive Securities Excluded From Computation Of Earnings Per Share, Shares	61,456	11,358

Goodwill and Other Intangible Assets Intangible Assets and Related Accumulated Amortization (Details) - USD ($)	9 Months Ended
	Sep. 30, 2016	Jun. 30, 2016	Dec. 31, 2015
Goodwill [Roll Forward]
Finite-Lived Intangible Assets, Gross	$ 5,700,000		$ 5,700,000
Finite-Lived Intangible Assets, Accumulated Amortization	(3,249,600)		(2,822,100)
Finite-Lived Intangible Assets, Future Amortization Expense	2,450,400	$ 2,450,400	2,877,900
Customer Lists [Member]
Goodwill [Roll Forward]
Finite-Lived Intangible Assets, Gross	1,000,000		1,000,000
Finite-Lived Intangible Assets, Accumulated Amortization	(570,100)		(495,100)
Finite-Lived Intangible Assets, Future Amortization Expense	$ 429,900		504,900
Finite-Lived Intangible Assets, Useful Life	10 years
Manufacturing Technology [Member]
Goodwill [Roll Forward]
Finite-Lived Intangible Assets, Gross	$ 3,900,000		3,900,000
Finite-Lived Intangible Assets, Accumulated Amortization	(2,223,400)		(1,930,900)
Finite-Lived Intangible Assets, Future Amortization Expense	$ 1,676,600		1,969,100
Finite-Lived Intangible Assets, Useful Life	10 years
Trade Names [Member]
Goodwill [Roll Forward]
Finite-Lived Intangible Assets, Gross	$ 800,000		800,000
Finite-Lived Intangible Assets, Accumulated Amortization	(456,100)		(396,100)
Finite-Lived Intangible Assets, Future Amortization Expense	$ 343,900		$ 403,900
Finite-Lived Intangible Assets, Useful Life	10 years

Goodwill and Other Intangible Assets Intangible Amortization Expense (Details) - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2016	Jun. 30, 2015	Jun. 30, 2016	Jun. 30, 2015
Finite-Lived Intangible Assets [Line Items]
Amortization of Intangible Assets	$ 142,500	$ 151,300	$ 427,500	$ 453,900
Cost of revenue
Finite-Lived Intangible Assets [Line Items]
Amortization of Intangible Assets	78,500	79,200	235,800	229,700
Research and development
Finite-Lived Intangible Assets [Line Items]
Amortization of Intangible Assets	19,000	27,100	56,700	89,200
Selling, general and administrative
Finite-Lived Intangible Assets [Line Items]
Amortization of Intangible Assets	$ 45,000	$ 45,000	$ 135,000	$ 135,000

Goodwill and Other Intangible Assets Goodwill (Details) - USD ($)	Sep. 30, 2016	Jun. 30, 2016	Dec. 31, 2015
Goodwill [Abstract]
Goodwill		$ 7,000,000
Future Amortization Expense, Year One		142,500
Future Amortization Expense, Year Two		570,000
Future Amortization Expense, Year Three		570,000
Future Amortization Expense, Year Four		570,000
Future, Amortization Expense, Year Five		570,000
Thereafter		27,900
Finite-Lived Intangible Assets, Future Amortization Expense	$ 2,450,400	$ 2,450,400	$ 2,877,900

Accrued Liabilities (Details) - USD ($)	Sep. 30, 2016	Dec. 31, 2015
Accrued Liabilities [Abstract]
Salaries, employee benefits and related taxes	$ 4,093,000	$ 2,771,200
Professional fees	376,700	480,700
Other	1,903,100	2,946,500
Accrued Liabilities	$ 6,372,800	$ 6,198,400

Debt (Details) - USD ($)		1 Months Ended	3 Months Ended			6 Months Ended
Debt (Details) - USD ($)	Mar. 11, 2016	Sep. 30, 2016	Jun. 30, 2016	Mar. 31, 2016	Jun. 30, 2015	Jun. 30, 2016	Jun. 30, 2015	Dec. 31, 2015	Sep. 26, 2014
Debt Instrument [Line Items]
Notes Payable			$ 1,000,000			$ 1,000,000		$ 1,800,000
Debt Instrument, Maximum Payment To Lender Based On Receipt Of Proceeds From Eligible Events				$ 3,000,000
Debt Issuance Cost				$ (100,000)
Long-term Debt and Capital Lease Obligations, Maturities, Repayments of Principal in Year Three			100,000			100,000
Long-term Debt and Capital Lease Obligations, Maturities, Repayments of Principal in Year Four			3,500,000			3,500,000
Long-term Debt and Capital Lease Obligations, Maturities, Repayments of Principal in Year Five			3,100,000			3,100,000
Long-term Debt			6,700,000			6,700,000
Interest expense			$ 200,000		$ 300,000	$ 700,000	$ 1,000,000
Impaired Long-Lived Assets Held and Used, Asset Name [Domain]
Debt Instrument [Line Items]
Debt Instrument, Periodic Payment, Interest				8.00%
Long-term Debt [Member]
Debt Instrument [Line Items]
Debt Instrument, Interest Rate, Stated Percentage Rate Range, Minimum				8.50%
Aspire Capital Purchase Agreement [Member]
Debt Instrument [Line Items]
Long-term Debt, Gross									$ 15,000,000
NeoStem, Inc. [Member] \| Long-term Debt [Member]
Debt Instrument [Line Items]
Debt Instrument, Payment Terms				21 months
Oxford Finance LLC [Member]
Debt Instrument [Line Items]
Repayments of Debt	$ 7,000,000	$ 3,000,000
Debt Instrument, Payment To Lender Based On Receipt Of Proceeds From Eligible Events, Percent				20.00%
Long-term Debt		5,700,000						$ 15,000,000
Long-term Debt, Maturities, Repayments of Principal in Next Twelve Months		$ 2,300,000

Redeemable Securities (Details) - USD ($) $ in Millions	Mar. 11, 2016	Mar. 31, 2016
Business Acquisition [Line Items]
Equity Method Investment, Ownership Percentage	19.90%
Hitachi Chemical Co., LTD [Member]
Business Acquisition [Line Items]
Recorded Unconditional Purchase Obligation	$ 19.4	$ 20.5
Equity Method Investment, Ownership Percentage	21.00%
Business Combination, Consideration Transfered, Interest Rate	2.00%

Shareholders' Equity - Reverse Stock Split (Details)	Jul. 28, 2016 $ / shares	Sep. 30, 2016 $ / shares	Dec. 31, 2015 $ / shares
Class of Stock [Line Items]
Common Stock, Par Value	$ 0.001	$ 0.001	$ 0.001
Reverse Stock Split, Conversion Ratio	0.1

Shareholders' Equity - Equity Issuances (Details)		1 Months Ended	3 Months Ended	9 Months Ended		12 Months Ended
Shareholders' Equity - Equity Issuances (Details)	Sep. 14, 2016 USD ($) clinical_trial_subject $ / shares shares	Nov. 30, 2015 USD ($) shares	Mar. 31, 2016 USD ($) shares	Sep. 30, 2016 USD ($) shares	Sep. 30, 2015 USD ($)	Dec. 31, 2016 USD ($) shares	Jun. 30, 2016 shares	Mar. 10, 2016 $ / shares shares	Dec. 31, 2015 shares	May 01, 2015 USD ($)
Class of Stock [Line Items]
Common Stock Warrants, Shares \| shares							362,399	141,844	321,404
Class of Warrant or Right, Exercise Price of Warrants or Rights \| $ / shares								$ 10.00
Share Price \| $ / shares								$ 7.05
Proceeds from Issuance of Warrants			$ 1,000,000
Shares Issued, Price Per Share \| $ / shares	$ 4.72
Net proceeds from issuance of common stock				$ 11,650,712	$ 36,136,839
Common Stock, Shares, Issued \| shares				8,181,921					5,673,302
RD Purchase Agreement [Member]
Class of Stock [Line Items]
Stock Issued During Period, Shares, New Issues \| shares	847,458
Proceeds from Issuance of Common Stock	$ 4,000,000
Private Purchase Agreement [Member]
Class of Stock [Line Items]
Stock Issued During Period, Shares, New Issues \| shares				1,398,305
Proceeds from Issuance of Common Stock				$ 6,600,000
Purchase Commitment, Maximum Amount Committed, Shares \| shares	4,449,153
Proceeds from Issuance of Common Stock, Initial Closing	$ 12,600,000
Proceeds from Issuance of Common Stock, Second Closing	$ 8,400,000
Number of Subjects, Phase 2 CLBS03 Clinical Trial, Second Closing \| clinical_trial_subject	70
Aspire Capital Purchase Agreement [Member]
Class of Stock [Line Items]
Purchase Commitment, Maximum Amount Committed, Shares \| shares		1,101,927.6
Purchase Commitment, Remaining Minimum Amount Committed		$ 30,000,000
Term of agreement in months		24 months
Stock Issued During Period, Shares, Other \| shares		84,269.6	5,000
Net proceeds from issuance of common stock			$ 30,000
Shares, Issued \| shares			109,270
Common Stock, Value, Issued			$ 300,000
Discount Applied To Weighted Average Price		5.00%
Aspire Capital Purchase Agreement [Member]
Class of Stock [Line Items]
Purchase Commitment, Remaining Minimum Amount Committed										$ 30,000,000
Common Stock, Shares, Issued \| shares			36,483.7
Subsequent Event [Member] \| Private Purchase Agreement [Member]
Class of Stock [Line Items]
Stock Issued During Period, Shares, New Issues \| shares						1,271,186
Proceeds from Issuance of Common Stock						$ 6,000,000

Shareholders' Equity - Stock options and warrants (Details)	6 Months Ended	12 Months Ended
	Jun. 30, 2016 USD ($) $ / shares $ / warrant shares	Dec. 31, 2015 USD ($) $ / shares $ / warrant shares	Mar. 10, 2016 shares
Stock Options and Warrants [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value \| $	$ 200	$ 100
Common Stock Warrants, Shares	362,399	321,404	141,844
Weighted Average Exercise Price, Warrants Outstanding \| $ / warrant	85.40	137.20
Weighted Average Remaining Contractual Term warrant outstanding	1 year 29 days	1 year 3 months 4 days
Aggregate Intrinsic Value, Warrants Outstanding \| $	$ 0	$ 0
Warrants Granted	141,845
Warrants Canceled	(100,850)
Weighted Average Exercise Price, Warrants Granted \| $ / shares	$ 10.00
Warrants Exercised	0
Weighted Average Exercise Price, Warrants Exercised \| $ / shares	$ 0.00
Warrants Expired	0
Weighted Average Exercise Price, Warrants Expired \| $ / shares	$ 0.00
Weighted Average Exercise Price, Warrants Canceled \| $ / shares	$ 145.10
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Aggregate Intrinsic Value \| $	$ 200
shares, vested and expected to vest	362,399
Weighted Average Exercise Price, Warrants vested & expected to vest \| $ / warrant	85.40
Aggregate Intrinsic Value, Warrants vested and expected to vest \| $	$ 0
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value \| $	$ 0
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number	362,650
Weighted Average Exercise Price, Warrants Exercisable \| $ / warrant	85.40
weighted Average Remaining Contractual Term, warrants vested	1 year 29 days
Aggregate Intrinsic Value, Warrants vested \| $	$ 0
US Equity Plan [Member]
Stock Options and Warrants [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number	942,129	666,348.0
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price \| $ / shares	$ 40.90	$ 64.60
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term	7 years 11 months 12 days	6 years 10 months 17 days
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Net of Forfeitures	448,365
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price \| $ / shares	$ 5.30
Stock Options Exercised	0
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price \| $ / shares	$ 0.00
Stock Options Expired	(61,983)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price \| $ / shares	$ 34.20
Stock Options Forfeited	(110,601)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price \| $ / shares	$ 45.90
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number	938,964
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price \| $ / shares	$ 41.10
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term	7 years 11 months 5 days
Weighted Average Remaining Contractual Term, Warrants Vested and Expect to Vest	1 year 29 days
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Number	761,371
Weighted average estimated fair value of shares granted \| $ / shares	$ 47.30
Options, Vested, weighted Average Remaining Contractual Term	7 years 7 months 24 days

Shareholders' Equity - Restricted Stock (Details) - USD ($)	6 Months Ended
	Jun. 30, 2016	Jun. 30, 2015
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Stock Issued During Period, Shares, Restricted Stock Award, Gross	107,719	81,184
Stock Issued During Period, Value, Restricted Stock Award, Gross	$ 651,700	$ 2,367,500
weighted average estimated fair value of restricted stock	$ 6.05	$ 29.16

Share-Based Compensation Share-Based Compensation (Details) - USD ($)	3 Months Ended		6 Months Ended		9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Jun. 30, 2016	Jun. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Allocated Share-based Compensation Expense	$ 335,500	$ 436,500			$ 2,275,600	$ 8,568,500
Stock Option [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Unrecognized compensation cost			$ 2,178,300
Expected weighted-average period in years of compensation cost to be recognized			1 year 3 months 15 days
Stock Options [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Weighted average estimated fair value of shares granted			$ 3.25	$ 21.03
Restricted Stock [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Unrecognized compensation cost			$ 454,000
Expected weighted-average period in years of compensation cost to be recognized			1 year 10 months 13 days
Cost of revenue
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Allocated Share-based Compensation Expense	11,700	14,400			306,300	509,500
Research and development
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Allocated Share-based Compensation Expense	6,000	115,900			298,300	1,642,800
Selling, General and Administrative Expenses [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Allocated Share-based Compensation Expense	$ 317,800	$ 306,200			$ 1,671,000	$ 6,416,200
Stock Option [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total fair value of shares vested			$ 2,189,400	$ 5,303,900

Income Taxes Net Operating Loss Carry Forward (Details) - USD ($)	Sep. 30, 2016	Dec. 31, 2015
Operating Loss Carryforwards [Line Items]
Operating Loss Carryforwards		$ 221,500,000
Deferred Tax Liabilities, Net, Noncurrent	$ 1,079,948	$ 932,662

Commitments and Contingencies (Details)		3 Months Ended	6 Months Ended
Commitments and Contingencies (Details)	Feb. 19, 2015 USD ($) ft² renewal_term	Mar. 31, 2015 USD ($)	Jun. 30, 2016 USD ($)	Mar. 31, 2016 USD ($)	Mar. 11, 2016 USD ($)
Operating Leased Assets [Line Items]
Equity Method Investment, Ownership Percentage					19.90%
Operating Leases, Future Minimum Payments Due [Abstract]
2016			$ 520,300
2017			1,876,500
2018			1,046,700
2019			994,900
2020 and thereafter			960,200
Total minimum lease payments			5,398,600
Operating lease expense		$ 1,200,000	$ 1,500,000
NEW JERSEY
Operating Leased Assets [Line Items]
Operating lease, rentable space \| ft²	18,000
Operating leases, monthly rental payments	$ 31,875
Operating leases, number of renewal terms \| renewal_term	2
Lessee leasing arrangements, operating leases, renewal term	5 years
Proceeds from lease assignment	$ 580,000
Security deposit liability				$ 115,000
Hitachi Chemical Co., LTD [Member]
Operating Leased Assets [Line Items]
Recorded Unconditional Purchase Obligation				$ 20,500,000	$ 19,400,000
Equity Method Investment, Ownership Percentage					21.00%

Subsequent Events (Details) - Private Purchase Agreement [Member] - USD ($) $ in Millions	9 Months Ended	12 Months Ended
	Sep. 30, 2016	Dec. 31, 2016
Subsequent Event [Line Items]
Proceeds from Issuance of Common Stock	$ 6.6
Stock Issued During Period, Shares, New Issues	1,398,305
Subsequent Event [Member]
Subsequent Event [Line Items]
Proceeds from Issuance of Common Stock		$ 6.0
Stock Issued During Period, Shares, New Issues		1,271,186