UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

o

Rule 13d-1(b)

x

Rule 13d-1(c)

o

Rule 13d-1(d)

CUSIP No. 128058203

13G

1

Names of Reporting Persons
I.R.S. Identification Nos. of Above Persons (Entities Only).

Sanford

2

Check the Appropriate Box if a Member of a Group

(a)

o

(b)

x

This filing describes the reporting person’s relationship with other persons, but the reporting person does not affirm the existence of a group.

3

SEC Use Only

4

Citizenship or Place of Organization
North Dakota, United States

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With:

5

Sole Voting Power
0

6

Shared Voting Power
635,593

7

Sole Dispositive Power
0

8

Shared Dispositive Power
635,593

9

Aggregate Amount Beneficially Owned by Each Reporting Person
635,593

10

Check if the Aggregate Amount in Row (9) Excludes Certain Shares

Not applicable

11

Percent of Class Represented by Amount in Row (9)
9.70375%

12

Type of Reporting Person
CO

CUSIP No. 128058203

13G

1

Names of Reporting Persons
I.R.S. Identification Nos. of Above Persons (Entities Only).

Sanford Health

2

Check the Appropriate Box if a Member of a Group

(a)

o

(b)

x

This filing describes the reporting person’s relationship with other persons, but the reporting person does not affirm the existence of a group.

3

SEC Use Only

4

Citizenship or Place of Organization
South Dakota, United States

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With:

5

Sole Voting Power
0

6

Shared Voting Power
635,593

7

Sole Dispositive Power
0

8

Shared Dispositive Power
635,593

9

Aggregate Amount Beneficially Owned by Each Reporting Person
635,593

10

Check if the Aggregate Amount in Row (9) Excludes Certain Shares

Not applicable

11

Percent of Class Represented by Amount in Row (9)
9.70375%

12

Type of Reporting Person
CO

Item 1.

(a)

Name of Issuer
Caladrius Biosciences, Inc.

(b)

Address of Issuer’s Principal Executive Offices
106 Allen Road, Fourth Floor

Basking Ridge, NJ 07920

Item 2.

(a)

Name of Person Filing
Each of the following is hereinafter individually referred to as a “Reporting Person” and collectively as the “Reporting Persons.” This statement is filed on behalf of:

Sanford

Sanford Health(1)

(b)

Address of Principal Business Office or, if none, Residence
The Principal Business Office of Sanford is: 801 Broadway N Fargo, North Dakota, 58122

The Principal Business Office of Sanford Health is: 1305 W. 18th St., Sioux Falls, South Dakota 57105

(c)

Citizenship
Sanford is organized under the laws of the State of North Dakota, United States

Sanford Health is organized under the laws of the State of South Dakota, United States

(d)

Title of Class of Securities
Common Stock

(e)

CUSIP Number
128058203

Item 3.

If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:

(a)

o

Broker or dealer registered under section 15 of the Act.

(b)

o

Bank as defined in section 3(a)(6) of the Act.

(c)

o

Insurance company as defined in section 3(a)(19) of the Act.

(d)

o

Investment company registered under section 8 of the Investment Company Act of 1940.

(e)

o

An investment adviser in accordance with §240.13d-1(b)(1)(ii)(E).

(f)

o

An employee benefit plan or endowment fund in accordance with §240.13d-1(b)(1)(ii)(F).

(g)

o

A parent holding company or control person in accordance with §240.13d-1(b)(1)(ii)(G).

(h)

o

A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act.

(i)

o

A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940.

(j)

o

Group, in accordance with § 240.13d-1(b)(1)(ii)(J).

Item 4.

Ownership

(a)

Amount beneficially owned   

635,593(2)

(b)

Percent of class

9.70375%

(c)

Number of shares as to which such person has:

(i)

Sole power to vote or to direct the vote   

0

(ii)

Shared power to vote or to direct the vote    

635,593

(iii)

Sole power to dispose or to direct the disposition of   

0

(iv)

Shared power to dispose or to direct the disposition of   

635,593

Item 5.

Ownership of Five Percent or Less of a Class

Not Applicable

Item 6.

Ownership of More than Five Percent on Behalf of Another Person.

Not Applicable

Item 7.

Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person.

Not Applicable

Item 8.

Identification and Classification of Members of the Group

Not Applicable

Item 9.

Notice of Dissolution of Group

Not Applicable

Item 10.

Certification

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

September 21, 2016

Sanford

/s/ Rich Adcock

Signature

Rich Adcock

Chief Innovation Officer

Name/Title

Sanford Health

/s/ Rich Adcock

Signature

Rich Adcock

Chief Innovation Officer

Name/Title

Sanford

By:

/s/ Rich Adcock

Name:

Rich Adcock

Title:

Chief Innovation Officer

Sanford Health

By:

/s/ Rich Adcock

Name:

Rich Adcock

Title:

Chief Innovation Officer